Diseases that Exhibit Similar Symptoms

Secondary syphilis

Secondary syphilis can produce almost any type of generalized rash, including pustules. The rash may appear anywhere on the body, and may involve the palms and soles. (19:9)

Clinical clues for differential diagnosis (22:V4:30) are that a secondary syphilis rash can mimic many diseases, the rash may involve palms and soles, 95% of syphilis rashes are maculo-papular, or may be pustular, and that it is found in sexually active persons. 

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