Browsing by Subject "Asthma"
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Item Acute and chronic Mycoplasma pneumoniae respiratory tract infection and its association with asthma(2004-09-09) Hardy, R. DougItem Allergic asthma: the dawn of quantitative understanding and rational therapy(1984-09-27) Sullivan, Timothy J.Item Anti-TSLP treatment of severe asthma: game changer of just another new kid on the block?(2021-12-17) Gruchalla, Rebecca S.Item Asthma(1965-03-11) UnknownItem Asthma and gastroesophageal reflux(1995-03-09) Pitcher, William DouglasItem Asthma management in the next millennium: a new dimension: role of Leukotriene modifiers(1998-01-29) Gruchalla, Rebecca S.Item Asthma: emerging concepts in pathophysiology and clinical management(1987-08-13) Kennerly, Donald A.Item [Asthma](1958-11-06) UnknownItem Emergent management of asthma(1989-02-09) Haddox, Robert J.Item Eosinophilic lung disease(2017-02-10) Weissler, Jonathan C.Item Hippocampal Volume Changes in Patients with Asthma(2015-01-26) Carlson, Scott; Jeon-Slaughter, Haekyung; Kim, Julie; Khan, David A.; King, Kevin; Lucarelli, Richard T.; McColl, Roderick; Peshock, Ronald M.; Brown, E. SherwoodBACKGROUND: Prior research suggests a possible association between asthma and decreased hippocampal volumes. OBJECTIVE: This study examines the association between asthma and hippocampal volume. METHODS: We conducted an analysis of participants in the Dallas Heart Study (DHS). The DHS collected an epidemiological sample of Dallas County residents to explore risk factors for heart disease. Included were 1,287 adults with complete data on study variables and without history of stroke, emphysema, or more than 5 drinks per day. Study variables included gender, age, race, and education as demographic characteristics, cognitive ability measured by the Montreal Cognitive Assessment (MoCA), and brain segment volumes measured by FreeSurfer. Study outcome variables were total, right, and left hippocampal volumes measured using FreeSurfer. General Linear Models (GLM) were conducted to examine the association of asthma diagnosis with hippocampal volumes after controlling for demographic characteristics, total MoCA score, and brain segment volume. Analysis of Variance (ANOVA) was used to examine the effect of gender on hippocampal volumes. RESULTS: The prevalence of lifetime asthma diagnosis among our study samples was 10.8% with 9.6% in males and 11.7% in females. Our study participants with a self-reported asthma diagnosis had significantly smaller estimated total, right, and left hippocampal volumes (95% CI 0.13%-2.9%; p = 0.03) than those without an asthma diagnosis. Asthma was significantly associated with total, right, and left hippocampal volumes in males, while not significantly associated in females after controlling for demographic characteristics, total MoCA score, and brain segment volume. Total, right, and left hippocampal volumes of males with asthma diagnoses, respectively, were 3.0% smaller (95% CI 0.77%-5.2%; p = 0.008), 2.9% smaller (95% CI 0.58%-5.2%; p = 0.014), and 3.1% smaller (95% CI 0.70%-5.6%; p =0.012) than males without asthma. CONCLUSION: Hippocampal volume in a large and diverse sample of adults was significantly smaller in people with asthma as compared to those without asthma. This difference in volume was limited to males. These findings suggest that asthma may be associated with structural brain differences as well as respiratory effects. Because the hippocampus is a brain region involved in memory formation these findings may have implications for treatment adherence.Item Investigating Personality Factors in Patients with Asthma(2020-08-01T05:00:00.000Z) Najjab, Aysha Gabrielle; Brown, E. Sherwood; Robinson, Richard C.; Robbins, Mona; Khan, Dave; Palka, JaymeTraits defined by the Five-Factor Model (FFM) of personality have been linked to physical health, leading to treatment implications and psychophysiological conceptualizations. Previous studies have reported a consistent association between neuroticism and asthma. This study aims to reinforce this finding and further its scope by looking at all five personality traits and lifetime asthma diagnosis. The current study examined associations between personality traits and lifetime asthma diagnosis in a sample of 3,993 participants and, for the purposes of replication, a second sample of 1,692 participant siblings. Personality was measured at a single time point in adulthood (mean age: 53 years), while asthma diagnosis by a medical professional was self-reported across three time points over a range of 54 years. A binary logistic regression was performed to examine the association between FFM personality traits and the likelihood of having endorsed asthma at any time point. Higher scores in the traits of neuroticism (β = 0.024, p = .03, OR = 1.025) and openness (β = 0.041, p < .001, OR = 1.042) were associated with increased risk of lifetime asthma diagnosis, while the trait of conscientiousness (β = -0.034, p = .009, OR = 0.967) was associated with decreased risk of lifetime asthma diagnosis. The associations with neuroticism and openness were replicated in the sibling sample. These findings suggest that research into certain personality traits might help us better understand psychophysiological connections. Neuroticism, openness, and conscientiousness might be salient factors in developing asthma education and treatment.Item Is asthma curable?: an inflammatory perspective(1989-06-01) Sullivan, Timothy J.Item Limitations to exercise in patients with chronic lung diseases(1984-12-20) Cassidy, Sharon S.Item [News](1975-03-11) Harrell, AnnItem [News](1984-05-07) Rutherford, SusanItem [News](1976-06-01) Harrell, AnnItem Occupational asthma: what can it teach us?(2005-02-10) Glazer, Craig S.Item Progress is [sic] asthma: from cytokine promotors [sic] & emerging pharmacotherapy to practical pitfals [sic] and & [sic] political barriers(1996-07-18) Kennerly, Donald A.In addition to the main protocol, another section for additional reading was distributed during this session. This was a 14-page compilation of the summary statements found in the following article: J Allergy Clin Immunol. 1995 Nov; 96(5 Pt 2): 707-870. http://www.ncbi.nlm.nih.gov/pubmed/7494078Item The Quick Inventory of Depressive Symptomatology, Self-Report (QIDS-SR16): A Psychometric Evaluation in Patients with Asthma and Major Depression(2006-05-15) Murray, Michelle; Rush, A. JohnSTATEMENT OF THE PROBLEM: Despite research evidence of high comorbidity between depression and asthma, few studies have addressed the performance of assessment tools which may assist physicians in assessing depression among asthma patients. The present study is the first to evaluate the psychometric properties of the self-report Quick Inventory of Depressive Symptomatology (QIDS-SR16), a 16-item measure of depressive symptom severity, in asthma patients. METHODS: The psychometric properties of the QIDS-SR16 are compared and evaluated in relation to the self-report Inventory of Depressive Symptomatology (IDS-SR30) and the17-item, clinician-rated Hamilton Rating Scale for Depression (HRSD17) in 73 asthma outpatients treated for nonpsychotic Major Depressive Disorder. Correlations between the depression rating scales and the Mini Asthma Quality of Life Questionnaire (MiniAQLQ) were calculated. RESULTS: Internal consistency at exit was strong for the QIDS-SR16 (Cronbach's a =.87) and the IDS-SR30 (Cronbach's a =.95). Total scores for the QIDS-SR16 showed high correlations with the HRSD17 (.85) and the IDS-SR30 (.97) total scores. One-hundred percent of the QIDS-SR16 items and 93% of the IDS-SR30 item-total score correlations reached statistical significance of p<.0001. The QIDS-SR16, the IDS-SR30, and the HRSD17 showed comparable sensitivity to symptom change, indicating high concurrent validity for all three scales. The total QIDS-SR16 baseline to exit change score demonstrated a significant negative correlation to the MiniAQLQ, providing another indicator of concurrent validity. CONCLUSIONS: The QIDS-SR16 shows good reliability and impressive construct validity, including test homogeneity, content validity, and concurrent validity. Strong psychometric properties as well as a self-report format, brief administration time, and sensitivity to treatment change make the QIDS-SR16 a valuable clinical and research instrument.