Browsing by Subject "Atrial Fibrillation"
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Item AF & HF: a convergence of epidemics(2011-04-08) Obel, Owen A.Item Altered Atrial Remodeling in the Muscular Dystrophies(2019-01-22) Kappalayil, Anishka; Patel, Vishal; Cheeran, Daniel; Tassin, Tara C.; Zaha, Vlad; Peshock, Ronald M.; Mammen, Pradeep P. A.INTRODUCTION: Muscular dystrophies (MD) are genetic disorders that cause progressive peripheral skeletal myopathies. The specific mutations lead to a cycle of muscle degeneration and regeneration in MD patients, ultimately producing progressive skeletal muscle wasting. Many of the MD patients also develop associated cardiomyopathies and in 2018 is the leading cause of death. Our group has demonstrated that MD patients have very small left ventricular (LV) masses as well as depressed LVEF. This data suggest that the mode of maladaptive cardiac remodeling may be different in MD vs NICM patients. However, it remains unknown the degree of atrial remodeling that occurs in MD patients. Therefore, the central hypothesis of this study is that atrial remodeling in MD patients is altered in comparison to non-ischemic cardiomyopathy patients. METHODS: Utilizing the UTSouthwestern Cardiomyopathy Clinic, MD and NICM patients were identified. Data was extracted from cardiac MRIs to measure left atrial (LA) volumes and function. The variables used were the LA end systolic volume (LA-ESV), LA end diastolic volume (LA-EDV), and LA ejection fraction (LAEF). These measures were normalized to the body surface area (BSA). We collected data on 78 MD patients (33 MD females, 45 MD males) and 80 NICM patients (28 NICM females, 52 NICM males). Utilizing unpaired two-sided T-test, LA data was analyzed between the matched MD and NICM patients. RESULTS: The MD and NICM patient cohorts showed significant differences in the LA structure and function. CONCLUSION: Collectively, the data suggests alternative mode of maladaptive cardiac remodeling in MD vs NICM patients. Thus, further investigation into the mechanism that leads to MD-associated cardiomyopathy may ultimately identify novel therapeutic targets for the amelioration of this disease entity.Item Atrial fibrillation in 2017: how times have changed!(2017-07-28) Link, MarkItem Atrial fibrillation: current treatment options and future therapies(2008-08-22) Wu, Richard C.Item Cardiac fibrosis: an unexplored therapeutic target for rhythm disorders(2010-05-07) Naseem, R. HarisItem Current interventional strategies for the management of atrial fibrillation(2006-03-16) Obel, Owen A.Item Dilemmas in the management of atrial fibrillation(1996-01-11) Malloy, Craig R.Item Left Atrial Enlargement Is Related to Diastolic Dysfunction in Obese Subjects(2017-01-17) Aiad, Norman N.; Sarma, Satyam; Hieda, Michinari; Levine, Benjamin D.PURPOSE: Obesity is linked to diastolic dysfunction and left atrial enlargement (LAE). The mechanisms responsible for LAE in obesity are unknown. We hypothesized that diastolic dysfunction, which is common in obesity, is the mechanism through which LAE occurs. METHODS: 27 middle-aged, obese patients (8M: 19F, 49±7years) with an average body mass index (BMI) of 38 ±5 kg/m2 were compared to age and sex matched non-obese healthy controls. Diastolic function (IVRT; isovolumic relaxation time, Vp: propagation velocity) was assessed using echocardiography. Left atrium (LA) size was measured using 3D echocardiogram, and normalized to height to account for the effects of body size. RESULTS: Obese individuals had a significantly enlarged atrial volume when compared to healthy individuals (35.9 ± 8 vs. 19.4 ± 10.5 mL/m; p<0.01). Obese patients had a significantly shorter IVRT when compared to non-obese patients (68 ± 11 vs 100 ± 16 msec; p<0.01). Obese patients also had a significantly faster Vp when compared to non-obese patients (75 ± 19 vs 56 ± 13 cm/sec; p<0.01). In obese subjects, there was a significant negative-relationship between LA volume index and IVRT (R2=0.27; p<0.05) as well as a significant positive-relationship between LA volume index and Vp (R2=0.18; p<0.05). CONCLUSIONS: Obese patients have larger LA and markers of elevated LA filling pressures (IVRT and Vp) compared to age matched controls. LAE in obesity may be a driven by sub-clinical alterations in diastolic function and left atrial filling pressures.Item Topics in anticoagulation(2016-07-29) Steen, Eric M.Item Update on drugs for outpatient management of atrial fibrillation(2015-05-29) Malloy, Craig R.