Browsing by Subject "Esophagus"
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Item Barrett's Esophagus: current understanding and controversies(2021-11-19) Vanderveldt, Hendrikus S.Item Cancer of the esophagus(1995-06-29) Goldschmiedt, MarkusItem Current and emerging concepts in Barrett's Esophagus(2007-02-23) Souza, Rhonda F.Item Dysphagia of esophageal origin(1965-12-16) UnknownItem Esophageal achalasia syndromes(1987-09-03) Feldman, MarkItem Nuclear Receptor FTZ-F1 and Downstream Target Gene Meg-8.3 Control Esophageal Gland Function in S. Mansoni(August 2021) Romero, Aracely Alicia; Reese, Michael L.; Collins, James J.; Mangelsdorf, David J.; Phillips, Margaret A.; Kliewer, Steven A.Schistosomes infect over 200 million of the world's poorest people, yet treatment relies on a single drug. Nuclear hormone receptors are ligand-activated transcription factors that regulate diverse processes in metazoans and are known drug targets in humans. However, few nuclear hormone receptors have been characterized functionally in the parasite. During a systematic analysis of nuclear receptor function, we have identified one receptor, an FTZ-F1-like receptor that is essential for parasite survival. Using a combination of transcriptional profiling and chromatin immunoprecipitation we identify the micro-exon gene, meg-8.3, a direct transcriptional target of FTZ-F1 which is also essential for parasite survival. We find that RNAi of either ftz-f1 or meg-8.3 are required for esophageal gland function and maintenance of tissue in the worm head. Together, our data suggest that FTZ-F1 regulates meg-8.3 transcription, and this regulation is essential to esophageal gland function. These data suggest that drugs that alter the activities of proteins in the parasite's esophageal gland could have therapeutic potential.Item Reflux: beyond the burn(2017-06-02) Mithani, RozinaItem [Southwestern News](2005-03-16) Maier, Scott