Browsing by Subject "Models, Statistical"
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Item Bayesian Spatial Analysis of High Throughput Sequencing Data(2021-05-01T05:00:00.000Z) Zhang, Minzhe; Mendell, Joshua T.; Nijhawan, Deepak; Zhan, Xiaowei; Xie, Yang; Xiao, GuanghuaThe past decade has witnessed the development and wide use of high-throughput sequencing data in biology. The recent advancement of RNA Sequencing (RNA-Seq) coupled with other molecular technologies such as methylated RNA immunoprecipitation (MeRIP) and spatial barcoding has delivered more specialized platform to investigate certain cellular process and spatial molecular profiling. However, the development of associated analysis tools capable of accommodating the unique features of these new sequencing technologies is still lacking or unsatisfied. For the past few years, I have been devoting to the methodology development of MeRIP-Seq and spatial molecular profiling data. The proposed BaySeqPeak and BOOST-GP methods demonstrated good accuracy, sensitivity and robustness in identifying methylated RNA region and spatial variable genes in both the simulation study and real data analysis.Item Donald W. Seldin, M.D., Research Symposium finalist presentations(2020-05-29) Adomako, Emmanuel; Hinkamp, Colin; Liu, Po-Hong (Stuart); McAdams, Meredith; Omar, Wally; Segar, MatthewThis edition of the UT Southwestern Internal Medicine Grand Rounds features presentations by the six Foster Fellows selected as finalists from the Fifth Annual Donald W. Seldin, M.D. Research Symposium, which was held on May 21, 2020. These Foster Fellows presented work that spanned the breadth and depth of scholarly activity across the department, and at the close of Grand Rounds, one will be selected as the 2020 Seldin Scholar, in honor of Dr. Donald W. Seldin. The Grand Rounds presentation also includes additional awards honoring Clinical Vignettes and an award for work in Quality and Education at Parkland Hospital.Item Using biomarkers to add precision to cardiovascular medicine, prevention and population health: hype or hope?(2021-07-30) de Lemos, JamesItem [UT Southwestern Medical Center News](2008-06-02) Stafford, Erin Prather