Browsing by Subject "Precision Medicine"
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Item Atypical diabetes mellitus: beginning of precision medicine(2018-01-19) Garg, AbhimanyuItem The challenge of precision medicine: ethical, legal & clinical issues in genomic medicine (The Daniel W. Foster, M.D., Visiting Lectureship in Medical Ethics)(2015-11-03) Wolf, Susan M.Genomics is advancing at a tremendous rate, bringing powerful new capabilities but also big challenges to clinical practice and research. With the federal government launching the Precision Medicine Initiative, the time to face those challenges is now. Genomic medicine raises fundamental issues including the role of patient choice, the development of quality standards, the privacy of sequence data, return of results and incidental findings, protection of patient privacy, and responsibilities to share information with the family. This lecture will analyze those challenges and suggest a way forward in biomedical research as well as clinical care.Item Chronic disease management and the shifting sands of payment reform(2018-04-20) Kermani, AsraItem Donald W. Seldin, M.D., Research Symposium finalist presentations(2021-04-23) Arvind, Ashwini; Elias, Roy; McAdams, Meredith; Salazar, Alonso Pezo; Rao, Shreya; Sheth, RahulThis edition of the UT Southwestern Internal Medicine Grand Rounds features presentations by the six Foster Fellows selected as finalists from the Sixth Annual Donald W. Seldin, M.D. Research Symposium, which was held on April 23, 2021. These Foster Fellows presented work that spanned the breadth and depth of scholarly activity across the department, and at the close of Grand Rounds, one will be selected as the 2021 Seldin Scholar, in honor of Dr. Donald W. Seldin. The Grand Rounds presentation also includes additional awards honoring Clinical Vignettes and an award for work in Quality and Education at Parkland Hospital.Item Kidney Precision Medicine Project: scientific foundation for improving care(2019-07-26) Miller, R. Tyler; Moe, Orson W.; Toto, Robert D.; Vazquez, Miguel A.Item Metabolism and nutrition in sepsis: a need for precision medicine(2021-06-04) Huen, SarahItem Precision cardiovascular medicine in the post-genomic era(2020-01-03) Munshi, NikhilItem Surgical and Conservative Treatment Approaches in Cases of Central Cord Syndrome: A Systematic Review and Meta-Analysis(2024-01-30) Venkatesh, Pooja; Jenkins, Abigail; Anand, Soummitra; Farid, Michael; Bah, Momodou G.; Barrie, Umaru; Wilson, Remi; Hall, Kristen; Caldwell, Christie; Al Tamimi, Mazin; Aoun, SalahINTRODUCTION: Management of central cord syndrome (CCS) is still controversial. This study aimed to examine the roles and timing of conservative and surgical management in CCS. METHODS: A systematic review was conducted according to the PRISMA guidelines to identify articles describing the use of conservative and/or surgical methods in the management of CCS. Data extracted was subsequently meta-analyzed. RESULTS: A total of 37 articles detailing 99 cases of adult CCS were identified with 79 males and 20 females. Patients receiving surgery were all female patients (100% vs. 0%, p<0.05), and had higher rates of established spondylosis (43.2% vs. 11.8%, p<0.05). Conservative management was more frequent in cases of CCS from sports trauma (35.3% vs. 1.23%, p=0.0000) and in patients presenting with upper extremity motor deficits at presentation (94.1% vs. 50.6%, p<0.01), symptoms of pain (52.9% vs. 21%, p<0.05), and autofusion on diagnostic imaging (29.4% vs. 1.23%, p=0.0001). Predictors of surgical intervention included a time lapse of >24 hours after injury (p<0.001, OR: 17.18, 95% CI: 3.00-182.81) and spondylosis on diagnostic imaging (p<0.01, OR: 8.84, 95% CI: 1.82-86.09). Additionally, surgical intervention was found to be less likely with increased patient age (p<0.01, OR: 0.96, 95% CI: 0.93-0.98). Meanwhile, sports trauma was a predictor of conservative management (p<0.001, OR: 0.03, 95% CI: 0.00-0.29). There was no statistically significant difference in symptomatic improvements between the two management strategies (87.7% vs 100%, p=0.2765). CONCLUSION: Understanding these predictors and outcomes can aid in personalized treatment decisions for CCS cases. Early surgical intervention within 24 hours of injury does not appear to be superior to conservative management with possible deferred operation.Item Using biomarkers to add precision to cardiovascular medicine, prevention and population health: hype or hope?(2021-07-30) de Lemos, James