Browsing by Subject "Psychiatry"
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Item Medical School plans seminar(1969-04-23) Chappell, Frank W., Jr.; Weeks, JohnItem [News Release](1969-01-28) Chappell, Frank W., Jr.; Fenley, BobItem [News](1971-01-21) Fenley, Bob; Weeks, JohnItem [News](1979-09-04) Williams, AnnItem [News](1981-03-04) Rutherford, SusanItem [News](1989-09-19) Harrell, AnnItem [News](1977-01-28) Weeks, JohnItem [News](1983-06-17) Harrell, AnnItem Severity of Illness Among Police-Escorted Psychiatric Emergency Room Patients Before and After the Implementation of a Regional, Public-Sector Managed Behavioral Health Care Program(2005-12-19) Baller, Mary S.; McConnel, CharlesManaged behavioral health care organizations are growing, but the clinical impact of managed care policies is largely unknown. The following study examines the clinical characteristics of police-escorted patients seen in the psychiatric emergency room of a large public hospital in metropolitan Dallas. Samples of patients seen in 1996 and 2004 are compared to determine whether an increase in severity of illness is evident, which demographic groups have been most vulnerable to changes in the system of care, and whether patients have become more overtly dangerous. Increased severity of illness among police-escorted psychiatric emergency room patients may be interpreted as a kind of cost-shifting as law enforcement officers and patients react to the diminishment of mental health resources in the managed care era.Item [Southwestern News](2004-01-31) Donihoo, RachelItem [Southwestern News](1994-10-19) Martinez, EmilyItem Special to Hospital News(1989-06-15) Harrell, AnnItem Two Psychological Survey Studies: (1) Understanding the Stigma Toward Lung Cancer and (2) Using Research Domain Criteria Project (RDoC) to Predict Remission Rates of Major Depressive Disorder Patients(2017-11-22) Ma, Tsung-wei; Zhan, Xiaowei; Xie, Yang; Xiao, Guanghua; Schiller, Joan H.; Gazdar, AdiThis dissertation is composed of two psychological survey studies. In the first study, people's negative attitudes toward lung cancer are assessed and discussed. The second topic is about predicting the remission rates of major depressive disorder patients with patients' self-reported questionnaires. In the first topic, I analyzed data from The Lung Cancer Project, an online survey study, to assess both explicit and implicit attitudes expressed by the four participant groups: health care professionals, cancer patients, caregivers and the general public. Negative attitudes toward lung cancer were detected among all these participant groups. I also discovered several demographic factors significantly associated with negative attitudes toward lung cancer. Furthermore, I investigated the association between state-level perceptions of lung cancer (including both explicit and implicit attitudes) and rates of treatment (drug treatment rates or total treatment rates, including surgery, chemotherapy, radiation, and immunotherapy) for lung cancer patients in the corresponding states. In the second topic, existing data from the Combining Medications to Enhance Depression Outcomes (CO-MED) trial were utilized to develop a data-driven method for mapping the behavioral factors to the constructs defined in Research Domain Criteria (RDoC). And I used the defined behavioral factors from CO-MED to discover patient subgroups. In further analysis, I found that the discovered patient subgroups have significantly different remission rates to the antidepressant treatment, which indicates that there are three endo-phenotypes in major depression disorder.Item [UT News](1986-08-22) Harrell, AnnItem Vulnerability and Resilience to Social Defeat: The Role of Neuroplasticity Within the Mesolimbic Dopamine Circuit(2010-05-14) Krishnan, Vaishnav; Nestler, Eric J.The pathophysiology of major depression and post-traumatic stress disorder are poorly understood. In particular, while stressful life events are an important cause of psychopathology, most individuals exposed to adversity maintain normal psychological functioning. The molecular mechanisms underlying this “resilience” are poorly understood. Here, we demonstrate that an inbred population of mice subjected to social defeat can be separated into susceptible and unsusceptible subpopulations which differ along several behavioral and physiological domains. Through a series of molecular and electrophysiological techniques, we identify signature adaptations within the mesolimbic dopamine circuit that are uniquely associated with vulnerability and, by a combination of viral-mediated gene transfer and genetic mouse models, we demonstrate how these adaptations are causally linked to a vulnerable phenotype. We also show that molecular recapitulations of adaptations associated with the unsusceptible phenotype are sufficient to promote resilient behavior. Our results validate a multidisciplinary approach to examine the neurobiological mechanisms of variations in stress resistance, and illustrate the importance of plasticity within the brain’s reward circuits in actively maintaining an emotional homeostasis.