Browsing by Subject "Synthetic Biology"
Now showing 1 - 3 of 3
- Results Per Page
- Sort Options
Item From reading the genome for risk to rewriting it for cardiovascular health(2022-10-28) Kathiresan, SekarItem Investigation of the Discoipyrroles and Other Marine Bacteria Derived Natural Products(2017-07-17) Colosimo, Dominic Andrew; Bruick, Richard K.; MacMillan, John; Ready, Joseph M.; Nijhawan, DeepakNatural products are a rich source of scientific innovation. These chemical compounds are canonically celebrated as biomedical tools or synthetic chemistry feats. Discovery of new chemical compounds has benefited from the study of natural product biosynthesis, or the methods by which they are constructed. Additionally, these studies have advanced the fields of ecology, industrial chemistry, and protein biophysics. This work will demonstrate how the discoipyrrole family of natural products inspired novel biomedical and biosynthetic discovery. In particular, their biosynthesis features unique mechanisms that are independent of protein catalysts, a growing trend found in natural products. Unrelated to the discoipyrroles, the manipulation of biosynthesis pathways using the methodology known as ribosome engineering will be discussed. This work demonstrates how the discovery and development of bioactive natural products can be enhanced by biosynthetic interrogations.Item (SYN) biology without borders: understanding the complexities and power of life?(2021-09-14) Kuiken, ToddOne of the many pressing issues the global community will confront in the next decade is whether the arsenal of biotechnologies should be deployed for conservation and environmental protection, or whether they are anathema to nature itself. How did we get to a point where we are contemplating whether to alter the DNA of species to save them from the impacts of humans? Do we really understand the complexities and power of life well enough to control it? Why are we so quick to alter and engineer nature, but so slow and unwilling to alter ourselves to protect it? Emerging biotechnologies, societies and environments are complex. Understanding these complexities requires a convergence of disciplinary study and thinking. Integrating knowledge from a variety of fields, cultures, and ethics. This talk will examine these complexities and how scientists, funders, businesses, regulators, and society at-large are contemplating if, how, and when these emergent biotechnologies should be used.