Browsing by Title
Now showing items 6423-6442 of 6843
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The U6 snRNA m6A Methyltransferase METTL16 Regulates MAT2A Intron Retention Through Co-Transcriptional Splicing
(2017-07-19)Maintenance of proper levels of the methyl donor S-adenosylmethionine (SAM) is critical for a wide variety of biological processes. We demonstrate that the N6-adenosine methyltransferase METTL16 regulates expression of ... -
Ubiquitin Conjugase UBE2K Is Essential for Normal Rat Development and Spermatogenesis
(2016-04-14)Animal models allow us to investigate questions about human physiology using in vivo systems. Following the advent of gene targeting by homologous recombination in mouse pluripotent embryonic stem cells during the early ... -
Ubiquitin Mediated Regulation of NF-kappa B Signaling
(2008-05-13)NF-κB signaling is involved in many vital cellular functions such as immunity, cell proliferation, inflammation, and apoptosis. The activation of NF-κB signaling requires the process of ubiquitination. K63-and K48-linked ... -
Ubiquitin, the Proteasome, and Dynamics at the Protein/DNA Interface
(2006-05-16)Recently it has been discovered that a mutant species of Gal4, that contains a three amino acid change in a surface loop of the DNA binding domain, does not occupy the GAL 1/10 promoter under Gal4 inducing conditions as ... -
Ubiquitination of EpoR and p85 in Ligand Induced EpoR Down-Regulation
(2014-07-09)Erythropoietin (Epo) is the primary cytokine that drives red blood cell production and signals through its receptor, the EpoR, on erythroid progenitor cells. Epo binding to EpoR activates Janus kinase 2 (JAK2), which ... -
Ubiquitination-Dependent Activation of IKK
(2005-12-19)Ubiquitination plays two different roles in the nuclear factor κΒ (NF-κΒ ) pathway, the traditional K48-linked polyubiquitination-mediated IκΒ degradation and the non-traditional K63-linked polyubiquitination-mediated IKK ... -
UCHLI in the Mammalian Nervous System
(2008-09-18)UCHL1, or Ubiquitin Carboxy Terminal Hydrolase L1, is a de-ubiquitinating enzyme (DUB) thought to be involved in ubiquitin recycling. Beyond this, its natural function is almost wholly unknown. Mice lacking this enzyme ... -
Ulcerative colitis
(1961-08-24) -
Ulcerative colitis
(1964-02-27) -
Ulcerative colitis and its complications
(1972-09-28) -
[Ulcerative colitis in children]
(1960-03-16) -
Ulcerogenic tumors
(1967-02-16) -
Unconjugated hyperbilirubinemia
(1966-01-13) -
Unconventional wisdom about the obesity epidemic
(2009-07-17) -
Uncovering Reversible AMPylation of BiP Mediated by dFic During ER Homeostasis
(2015-01-16)AMPylation is a posttranslational modification involving a covalent attachment of an AMP moiety from ATP to hydroxyl side chains of target substrates. Fic domain which mediates AMPylation is highly conserved across species, ... -
Uncovering the Complexity of RAS Signaling Networks
(2004-05-04)The Raf/MEK/MAP Kinase signal transduction cascade is a key Ras effector pathway that mediates diverse cellular responses to environmental cues, and makes a major contribution to Ras-dependent oncogenic transformation. ... -
Understanding Autism Pathology: Insights from Genetic Mouse Model Manipulation of KCTD13 and SHANK3
(2017-07-19)Copy number variations (CNVs) contribute to the etiology of Autism Spectrum Disorders (ASDs). Deletions/duplications in human chromosomal region 16p11.2 are frequently associated with ASD and other neurodevelopmental ...