Browsing by Subject "Hair Disease"
Now showing items 1-2 of 2
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The Role of Insig-Mediated Cholesterol Homeostasis in Mouse Hair Development
(2012-08-15)Insig-1 and Insig-2, two very homologous proteins, are indispensable for feedback inhibition of cholesterol biosynthesis. Mice null for both Insigs drastically overproduce cholesterol and its precursor sterol intermediates ... -
Role of Insig-Mediated Cholesterol Homeostasis in the Development of the Palate and Hair Follicles in Mice
(2012-08-15)Proper cholesterol homeostasis is crucial in mammalian development. Currently, there are 8 known human malformation syndromes due to genetic defects in cholesterol biosynthesis. Patients with these syndromes present with ...