Browsing by Subject "Quorum Sensing"
Now showing items 1-4 of 4
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The Characterization of Quorum Sensing E. Coli Regulators E,F, and G (Qse EFG) and Their Role in Pathogenesis
(2008-09-18)Escherichia coli O157:H7 (EHEC) causes hemorrhagic colitis and life-threatening hemolytic uremic syndrome (HUS) worldwide. EHEC colonizes the large intestine and adheres to intestinal epithelial cells by forming attaching ... -
Structural and Mechanistic Roles of Novel Chemical Ligands on Quorum Sensing Transcription Regulator SdiA in Enterohemorrhagic Escherichia coli
(2014-11-18)Microorganisms and their eukaryotic hosts have co-evolved for millions of years. How bacteria sense and adapt to different environments is still unclear. Most Gram-negative bacteria use the LuxR family of transcription ... -
Studies Toward the Syntheses of Antiarrythmic, Anti-Virulence, and Anticancer Small Molecules
(2015-11-23)This work is comprised of three projects: a) the development of antiarrythmic analogs of 17(R),18(S)-epoxyeicosatetraenoic acid for the treatment of atrial fibrillation, b) the development of potent inhibitors of QseC ... -
A Synthetic Quorum Sensing System Reveals Interaction Between Extracellular Matrix and Quorum Sensing Molecules
(2015-09-29)Even though bacteria are unicellular organisms, they commonly reside in structured communities known as biofilms. One of the defining characteristics of biofilms is the presence of an extracellular matrix (ECM) that ...