Browsing by Subject "T-Lymphocytes, Regulatory"
Now showing items 1-9 of 9
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Characterizing B Cell Phenotype During Chronic HCV Infection
(2009-06-15)Chronic hepatitis C virus (HCV) infection is characterized by an attenuation of virus-specific T cell responses. The mechanisms leading to T cell attenuation are still not well understood, and likely involve several ... -
Destruction of Corneal Nerves Promotes Corneal Allograft Rejection
(2014-06-11)The human corneal endothelium has very little regenerative capacities and cannot fully heal in response to infection or trauma. Evolutionarily, the eye developed a mechanism to retain visual acuity by protecting the eye ... -
Disease Exacerbation in Multiple Sclerosis Patients is Characterized by Loss of Terminally Differentiated CD8+ T Regulatory Cells
(2014-02-04)Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system (CNS) that afflicts more than 400,000 people in the US. Although the etiology of the disease is unknown, pathogenic T cells ... -
LRBA Restricts Murine Colitis by Regulating Interferon Responses and Autophagy
(2018-11-27)Lrba encodes lipopolysaccharide-responsive and beige like anchor (LRBA) protein, which was originally identified as an LPS-inducible gene in immune cells. LRBA putatively regulates the recycling and degradation of proteins ... -
Neuroantigen-Specific CD8+ Regulatory T-Cell Function Is Deficient During Acute Exacerbation of Multiple Sclerosis
(2013-05-31)Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system (CNS). MS is thought to be T-cell-mediated, with prior research predominantly focusing on CD4+ T-cells. There is a high ... -
Peripheral Generation of Regulatory T Cells in Health and Disease
(2007-05-23)CD4+CD25+FOXP3+ regulatory T cells (Tregs) form an important arm of the immune system responsible for suppressing untoward immune responses. They play a role in autoimmunity, allergy, asthma, transplantation, tumors and ... -
Preferential Regulatory T-Cell Generation from Memory CD4+ T-Cells Is Deficient During Acute Exacerbation of Multiple Sclerosis
(2014-06-11)Multiple sclerosis (MS) is an immune-mediated disease with reported defects in thymic T-cell output. Thymically-derived natural regulatory T-cells (nTregs) play a vital role in suppressing autoimmune responses. We have ... -
Role of Allergic Conjunctivitis in Inducing Corneal Transplant Rejection
(2013-01-17)Corneal allografts are the most commonly transplanted solid organs in humans and have a success rate of over 90%. This low incidence of graft rejection is largely due to the unique properties of the eye that decrease the ... -
Role of Splenic B Cells and Gamma Delta T Cells in the Induction of Peripheral Tolerance Elicited Through the Anterior Chamber of the Eye
(2006-12-19)Anterior chamber-associated immune deviation (ACAID) is a form of peripheral tolerance that is induced by introducing antigens into the anterior chamber (AC) of the eye, and is maintained by antigen-specific regulatory T ...