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Distinct Tau Strains: Exploring Variability in Cell Uptake and Seeding Using Heparinoids
BACKGROUND: Tauopathies (including Alzheimer's Disease) are incurable, progressive neurodegenerative diseases caused by tau protein aggregation. Evidence suggests that tau aggregates spread pathology as do prions, infectious ...
The University of Texas Southwestern Medical Center at Dallas Fifty-Sixth Annual Medical Student Research Forum
This 106-page booklet includes a list of oral presentations, a table of contents to the abstracts, and the abstracts divided by three categories: Basic Research and Disease Models, Clinical Research, Quality Improvement, ...
Molecular Characterization of Novel FOXN1 Mutations Causal to Thymic Aplasias in Human Patients
The Forkhead Box N1 (FOXN1) transcription factor plays a crucial role in thymic epithelial cell development. Humans and mice harboring FOXN1 mutations have a profound T-cell deficiency caused by their thymic aplasia. They ...
Oligonucleotide Primer Sequences
Zigman, J. M., & Rodriguez, J. A. Data from: Oligonucleotide primer sequences. UT Southwestern Institutional Repository 2018. Deposited 6 September 2018. http://hdl.handle.net/2152.5/5772
Exploring a Novel, Non-Invasive Treatment for Prosthetic Joint Infection
Periprosthetic joint infection (PJI) is a very prevalent consequence of implant surgery. The surface of the prosthesis provides a favorable environment for the growth of bacterial biofilms, which are notorious for being ...
Role of KIRREL in Mammalian Myogenesis and Rhabdomyosarcoma
Rhabdomyosarcoma is an aggressive soft-tissue malignancy comprised microscopically of neoplastic skeletal muscle-lineage precursors that fail to exit the cell-cycle and fuse into syncytial muscle - the underlying pathogenetic ...
Administration of Fatty Acid Emulsions to Reduce Secondary Brain Injury in Mice
BACKGROUND: Mild traumatic brain injuries are the most common type of injury to the head. Seventy-five to eighty percent of all traumatic brain injuries (TBI) are considered a mild TBI, or concussions, and involve only a ...
Antisense Blockade of Efflux Systems in Gram-Negative Pathogens
Antibiotic resistant bacteria, aka "super bugs", are a critical threat to public health worldwide, as the medical community is running out of effective antibiotics against a growing number of bacteria. One of the ways that ...
Thermal Eradication of Prosthetic Joint Associated Bacteria
PURPOSE: As with other medical implants, prosthetic joints provide a hospitable surface for bacterial adherence and biofilm formation. We are developing a non-invasive thermal technique to destroy biofilm on the metal ...
Calcitriol Treatment Suppresses Contraction-Associated Gene Expression in Pregnant Mice Near Term
Preterm birth (PTB) is the leading cause of infant mortality during the first four weeks of life world-wide. This is due, in part, to our incomplete understanding of the mechanisms that mediate uterine quiescence during ...