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One-Pot Measurement of the Kinetic Parameters KI, kinact, and Time-Dependent IC₅₀ for Analysis of Covalent Small Molecule Kinase Inhibitors
To address the need for the analysis of covalent kinase inhibitors in a high-throughput method, we established a protocol for the facile measurement of kinact and KI utilizing a proprietary off-chip mobility shift assay ...
Roles of Ascl1 and Olig2 in the Transcriptional Regulation of Astrocytogenesis
Ascl1 and Olig2 are transcription factors highly expressed in certain neural progenitor cells, and are known to be involved in neurogenesis and oligodendrogenesis (OL) throughout the CNS; their role in astrocytogenesis ...
Peripheral Blood Gene Expression in Discoid Lupus Erythematosus and Systemic Lupus Erythematosus Patients
BACKGROUND: Systemic lupus erythematosus (SLE) is an autoimmune disease with variations in clinical presentation that can affect the kidney, blood vessels, heart, lungs, joints, CNS, and/or the skin. The most common cutaneous ...
Does Reelin Affect Recovery from a Stroke?
Reelin is an extraceullular glycoprotein that modulates synaptic plasticity and increases long-term potentiation. Since Reelin has neuroprotective effects, we were interested to see if Reelin plays a role in recovery after ...
Distinct Tau Strains: Exploring Variability in Cell Uptake and Seeding Using Heparinoids
BACKGROUND: Tauopathies (including Alzheimer's Disease) are incurable, progressive neurodegenerative diseases caused by tau protein aggregation. Evidence suggests that tau aggregates spread pathology as do prions, infectious ...
The University of Texas Southwestern Medical Center at Dallas Fifty-Sixth Annual Medical Student Research Forum
This 106-page booklet includes a list of oral presentations, a table of contents to the abstracts, and the abstracts divided by three categories: Basic Research and Disease Models, Clinical Research, Quality Improvement, ...
Molecular Characterization of Novel FOXN1 Mutations Causal to Thymic Aplasias in Human Patients
The Forkhead Box N1 (FOXN1) transcription factor plays a crucial role in thymic epithelial cell development. Humans and mice harboring FOXN1 mutations have a profound T-cell deficiency caused by their thymic aplasia. They ...
Oligonucleotide Primer Sequences
Zigman, J. M., & Rodriguez, J. A. Data from: Oligonucleotide primer sequences. UT Southwestern Institutional Repository 2018. Deposited 6 September 2018. http://hdl.handle.net/2152.5/5772
Exploring a Novel, Non-Invasive Treatment for Prosthetic Joint Infection
Periprosthetic joint infection (PJI) is a very prevalent consequence of implant surgery. The surface of the prosthesis provides a favorable environment for the growth of bacterial biofilms, which are notorious for being ...
The Role of Ascl1 in NG2 Cells in the Spinal Cord
NG2 cells, one of the major glial cell populations within the central nervous system (CNS), are highly proliferative cells identified by the expression of the NG2 proteoglycan. Throughout life, NG2 cells can differentiate ...