Browsing Annual Medical Student Research Forum by Issue Date
Now showing items 1-20 of 285
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The Radiation Footprint on the Pediatric Trauma Patient
(2013-01-22)BACKGROUND: Overuse of radiation in patients has recently become an important topic of discussion within the medical community. Pediatric patients are most at risk. A recent study has proven the incidence of 1 brain tumor ... -
Confirmation of Hypoglycemia in Goat -/- Mice When Total Body Fat Falls below 2% of Body Weight
(2013-01-22)Ghrelin is an octanoylated peptide hormone first identified in stomach, with the octanoyl group being essential to its biological activity. The enzyme that attaches the octanoyl group to ghrelin is called Ghrelin-Oacyltransferase ... -
Folate Receptor Beta Targeting for In Vivo Optical Imaging of Head and Neck Squamous Cell Carcinoma
(2013-01-22)OBJECTIVE: The folate receptor (FR) is a high-affinity folic acid binding endocytic receptor uncommonly expressed in normal tissues. The α isoform (FR-α) is overexpressed in a variety of epithelial neoplastic cells. In ... -
AB1-42 Antibody Producing Plasma Cells in DNA AB42 Trimer Immunized Mice Reside Predominantly in the Bone Marrow
(2013-01-22)Alzheimer's disease (AD) is the most common form of age-related dementia and affects nearly 40 million people worldwide. Immunotherapy provides a possible avenue for prophylaxis of AD, but a clinical trial (AN1792) in which ... -
Cdk5-Dependent Regulation of Neuronal MEK1
(2013-01-22)INTRODUCTION: Cyclin-dependent protein kinase 5 (Cdk5) is a member of the Cdk family that is implicated in many regulatory pathways in post-mitotic neurons. The kinase plays an important role in neuronal development and ... -
Impact of Donor Age on Endothelium-Descemet Membrane Layer Harvesting and Roll Formation
(2013-01-22)PURPOSE: Descemet membrane endothelial keratoplasty (DMEK) is an alternative to Descemet's stripping automated endothelial keratoplasty (DSAEK) to surgically replace diseased corneal endothelium. Although graft rejection ... -
Obesity and Outcomes Following Burns in the Pediatric Population
(2013-01-22)PURPOSE: While obesity is associated with increased mortality and decreased functional outcomes in adult burn patients, the ramifications of larger than average body size in the pediatric burn population are less well ... -
Parameters that Predict for High Grade Rectal Toxicity in Prostate Cancer Patients Undergoing Stereotactic Body Radiation Therapy- Analysis of Phase I/II at UT Southwestern
(2013-01-22)INTRODUCTION: Conventional radiation therapy (CRT) is a well-accepted option for PCa treatment with high disease control rate, and low (< 3-5%) risk of rectal toxicity. SBRT, unlike CRT, delivers higher doses of radiation ... -
A Descriptive Analysis of Patient Encounter Data from the UT Southwestern Ede Jodi Humanitarian Relief Trip to Haiti
(2013-01-22)BACKGROUND: Every day, millions of Haitians struggle against hunger, poverty, and illness. This situation has been exacerbated in recent years by a series of hurricanes, famines, the 2010 earthquake, and the cholera outbreak, ... -
Severe Remote Burn Injury Results in Early, Elevated Markers of Alzheimer's Disease
(2013-01-22)BACKGROUND: Prior studies have found that patients with severe burns may suffer neurocognitive decline. While these observations are frequently attributed to psycho-social causes, our lab recently reported that remote burn ... -
Photoprotective Habits of Patients with Cutaneous Lupus Erythematosus
(2013-01-22)BACKGROUND/PURPOSE: Ultraviolet radiation is a well-documented trigger of skin lesions in patients with cutaneous lupus erythematosus (CLE). Though CLE patients are advised to practice photoprotection to prevent disease ... -
A Study of Trauma Memory in Survivors of the 9/11 Attacks Using the Deese-Roediger-McDermott (DRM) Memory Paradigm
(2013-01-22)BACKGROUND. PTSD has been found to be associated with abnormalities in memory function. This relationship has not previously been studied with the Deese-Roediger-McDermott (DRM) paradigm in disaster-exposed populations. ... -
Anti-VEGF Induced Reduction in Microvessel Density Does Not Correlate with Anti-Tumor Repsonse in Lung Cancer Xenografts
(2013-01-22)Vascular endothelial growth factor-A (VEGF) is a primary stimulant of angiogenesis in pathological conditions including tumor progression. Strategies to block VEGF activity prevent or slow tumor growth in preclinical ... -
Regulation of Pyruvate Kinase M2 (PKM2) Expression and Activity in Cardiac Hypertrophy
(2013-01-22)BACKGROUND: Cardiac hypertrophy is characterized by robust structural, metabolic, and signaling events, which include increased myocyte size and width, increased glycolytic flux, aerobic glycolysis, and induction of ... -
Searching for Genes of Host Defense
(2013-01-22)Through random mutation of the mouse genome and phenotypic screening of the mutated mice, genes can be identified that are associated with dysfunction in the innate immune system. The strategy proposed works under the ... -
Intravascular Ultrasonography Analysis of the Everolimus-Eluting Stent in Coronary Chronic Total Occlusions
(2013-01-22)PURPOSE: Coronary artery disease (CAD) is consistently the number one cause of death for both men and women worldwide. Of the millions of patients diagnosed with CAD, approximately 1 in 5 is found to have a coronary artery ... -
Anticoagulant Use is Associated with Improved Biochemical Control of High-Risk Prostate Cancer Patients Treated with Radiation Therapy
(2013-01-22)INTRODUCTION: The coagulation system modulates multiple cancer pathways, including tumor proliferation, angiogenesis, host immunologic defense, and metastasis. Prior studies have reported improved survival and freedom from ... -
Voluntary Exercise Alters Adaptive Immunity Prior to Injury
(2013-01-22)OBJECTIVE: Exercise provides a neuroprotective role in the setting of cerebral infarct. However, the exact mechanism for this protection is unclear. This study established an exercise preconditioning protocol to test the ... -
Impact of Ethnicity in Upper Gastrointestinal Hemorrhage
(2013-01-22)BACKGROUND AND AIMS: Upper gastrointestinal hemorrhage (UGIH) is a serious condition, with considerable morbidity and mortality. Thus, we aimed to examine the role of ethnicity in UGIH outcomes. METHODS: We analyzed 2196 ... -
The Wait for the Weight: Pediatricians' Communication about Weight to Overweight and Obese Latino Children and their Parents
(2013-01-22)BACKGROUND: Latinos are among the most overweight (OW) racial/ethnic groups of US children. It is unknown, however, whether language barriers impact the communication of childhood OW. Objective: To determine whether and ...