UT Southwestern Electronic Theses and Dissertations
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Welcome to the UT Southwestern Electronic Theses and Dissertations (ETD) community.
Most UT Southwestern ETDs are subject to a default embargo period of two (2) years from the date of degree conferral. These embargoed ETDs are unavailable until the embargo expires.
To verify whether an ETD is available or if you have other questions, please contact etd-utsw@utsouthwestern.edu.
Print theses and dissertations from 1943 to 2004 are located in the Library's Special Collections and Archives (Room E3.314) and are available by appointment. (Note: Former students may request a digitized copy of their work by email, but other users may submit an Interlibrary Loan request.) For more information, contact archives@utsouthwestern.edu.
Collections in this community
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UT Southwestern Graduate School of Biomedical Sciences
This collection contains ETDs produced by students of the UT Southwestern Graduate School. -
UT Southwestern Medical School
This collection contains ETDs produced by students of the UT Southwestern Medical School. -
UT Southwestern School of Health Professions
This collection contains ETDs produced by students of the UT Southwestern School of Health Professions (formerly UT Southwestern School of Allied Health Sciences).
Recent Submissions
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The Impact of Lipid Nanoparticle Chemistry on RNA Delivery and Therapeutic Outcomes
(2022-12-01)This dissertation aims to understand how two individual components of the traditional four-component lipid nanoparticle system, the PEG lipid component and the ionizable cationic lipid component, impact RNA delivery. To ... -
A Novel Role for HAPLN1 in Skeletal Development
(2022-12-01)Adolescent idiopathic scoliosis (AIS) is a potentially progressive spinal curvature that occurs during rapid growth and has a multi-factorial genetic etiology. Prior genetic studies in humans and animal models support ... -
Uncovering Molecular Determinants of Pathogenic Non-Coding Structural Variation in Leukemia Genomes
(2022-12-01)Non-coding structural variants (SVs) can rewire chromatin topologies to cause oncogene activation in cancer genomes, yet the molecular determinants for the transcriptional output mediated by SVs remain poorly understood. ... -
Translational Control by the Ribosome-Associated Complex in the Unfolded Protein Response
(2020-12-01)Ribosome-associated chaperones are ubiquitous and highly conserved. There are two classes of ribosome-associated chaperones in eukaryotes, the nascent polypeptide-associated complex (NAC) and the ribosome-associated complex ... -
Functional Studies of Stem Cells in the Parasitic Flatworm Schistosoma mansoni
(2020-12-01)Schistosomes are parasitic flatworms that infect over 200 million people, primarily in poverty-stricken developing countries, causing extensive morbidity and mortality. Schistosomes have a great deal in common with other ... -
The Influence of Demographic Factors, Resilience, and Other Psychological Factors in Predicting Caregiver Burden in Trauma ICU Populations
(2020-12-01)Although only a small number of studies specifically focus on caregivers of ICU patients, findings suggest that these caregivers can experience a substantial burden. Although negative psychological states, including ... -
Identification of Scavenger Receptor B1 as the Airway Microfold Receptor for Mycobacterium tuberculosis
(2020-12-01)Mycobacterium tuberculosis (Mtb) can enter the body through multiple routes, including via specialized transcytotic cells called microfold cells (M cell). However, the mechanistic basis for M cell entry remains undefined. ... -
Changes in the Gut Metabolic Landscape Drive Inflammation-Associated Dysbiosis and Host Responses
(2020-12-01)Intestinal inflammation is frequently associated with alterations in composition of gut microbial communities, termed dysbiosis. Inflammation-associated dysbiosis is characterized by an expansion of facultative anaerobic ... -
Development of Applications and Quantitative Frameworks for Multispectral Optoacoustic Tomography
(2020-12-01)The tumor microenvironment is a highly complex system, with variations through space and time that are determined by the interplay of normal and cancerous cells, physiological phenomena, and treatments that can dramatically ... -
Effects of Alcohol Use on Cognition During Later Adulthood
(2020-12-01)Alcohol is one of the most widely used psychoactive substance in the world, yet there are conflicting findings related to its long-term effect on cognition. Some research has identified a U-shaped relationship between ... -
Signal Transduction Pathways That Impact Polar Flagellar Biogenesis
(2020-12-01)Bacterial flagella are rotating nanomachines required for motility. Flagellar gene expression and protein secretion are coordinated for efficient flagellar biogenesis. Polar flagellates, unlike peritrichous bacteria, ... -
Synthetic Studies of the Rubellin Natural Products
(2020-12-01)The effective construction of complex bioactive molecules often requires the development of innovative chemical methods to push the boundaries of organic synthesis. As the utility of available reactions increases, the ... -
Assessing Approach Motivation in Depressed Individuals with a History of Concussion
(2020-12-01)Depression is the leading cause of disability worldwide. Anhedonia, a core symptom of depression, has been described as a lack of pleasure or interest, though it is a much more complex process than simply lack of pleasure. ... -
Evaluation of Social Stories in Sleep Treatment for Children with Autism Spectrum Disorder: A Feasibility Study
(2020-12-01)A majority of children with autism spectrum disorders (ASD) experience sleep disturbances which are apt to negatively impact cognition, behavioral functioning, and the general trajectory of psychosocial development. ... -
Structure and Function of the Alpha3Beta4 Nicotinic Acetylcholine Receptor
(2020-12-01)Nicotinic acetylcholine receptors are pentameric ligand-gated ion channels that are essential for the proper function of the central and peripheral nervous systems. The α3β4 subtype is highly expressed in the autonomic ... -
The Functional Roles for SWI/SNF Chromatin Remodeling Complexes in Physiology and Disease
(2020-12-01)Sequencing studies have implicated multiple subunits of SWI/SNF complexes in human neurodevelopmental and psychiatric disorders, as well as in cancers. Particularly haploinsufficiency of ARID1B, a SWI/SNF chromatin-remodeling ... -
Improving Protocol Adherence in Central Line Placements
(2022-05-01)BACKGROUND: The placement of central lines is a very common exercise in medicine. Central lines are required for everything from acute trauma scenarios to long term cancer treatments. However, this ubiquitous procedure has ... -
Transcription Factor Dynamics Investigated through Single-Molecule Imaging, High-Throughput Sequencing, and Neural Networks
(2020-08-01)Recent chromatin characterization and sequencing technologies, paired with growing power in computational and bioinformatic analysis, have enabled a deeper understanding of the highly sequence-dependent nature of protein-DNA ... -
Characterizing Renal Interstitial Heterogeneity and Its Role in Nephron Patterning
(2020-08-01)Chronic kidney disease (CKD) is a growing national health concern affecting 30 million Americans. CKD can lead to permanent loss of kidney function requiring treatment for survival, yet the only two treatment options, ... -
Novel Roles for BET Bromodomain Protein 4 (BRD4) in Cardiac Physiology and Disease
(2020-08-01)Bromodomain (BRD) protein of the BET (Bromodomain and Extra-Terminal) family are epigenetic reader proteins that have emerged as novel therapeutic targets in cardiovascular disease as well as in a variety of cancers. Small ...