• The Impact of Lipid Nanoparticle Chemistry on RNA Delivery and Therapeutic Outcomes 

  Johnson, Lindsay Taylor; 0000-0002-4563-5486 (2022-12-01)

  This dissertation aims to understand how two individual components of the traditional four-component lipid nanoparticle system, the PEG lipid component and the ionizable cationic lipid component, impact RNA delivery. To ...

• A Novel Role for HAPLN1 in Skeletal Development 

  Patel, Chandreshkumar Vishnubhai; 0000-0001-7437-7036 (2022-12-01)

  Adolescent idiopathic scoliosis (AIS) is a potentially progressive spinal curvature that occurs during rapid growth and has a multi-factorial genetic etiology. Prior genetic studies in humans and animal models support ...

• Uncovering Molecular Determinants of Pathogenic Non-Coding Structural Variation in Leukemia Genomes 

  Botten, Giovanni Angelo; 0000-0001-8054-8030 (2022-12-01)

  Non-coding structural variants (SVs) can rewire chromatin topologies to cause oncogene activation in cancer genomes, yet the molecular determinants for the transcriptional output mediated by SVs remain poorly understood. ...

• Translational Control by the Ribosome-Associated Complex in the Unfolded Protein Response 

  Wu, I-Hui; 0000-0002-7115-239X (2020-12-01)

  Ribosome-associated chaperones are ubiquitous and highly conserved. There are two classes of ribosome-associated chaperones in eukaryotes, the nascent polypeptide-associated complex (NAC) and the ribosome-associated complex ...

• Functional Studies of Stem Cells in the Parasitic Flatworm Schistosoma mansoni 

  Wendt, George R.; 0000-0002-8302-079X (2020-12-01)

  Schistosomes are parasitic flatworms that infect over 200 million people, primarily in poverty-stricken developing countries, causing extensive morbidity and mortality. Schistosomes have a great deal in common with other ...

• The Influence of Demographic Factors, Resilience, and Other Psychological Factors in Predicting Caregiver Burden in Trauma ICU Populations 

  Patel, Sarita; 0000-0003-2935-215X (2020-12-01)

  Although only a small number of studies specifically focus on caregivers of ICU patients, findings suggest that these caregivers can experience a substantial burden. Although negative psychological states, including ...

• Identification of Scavenger Receptor B1 as the Airway Microfold Receptor for Mycobacterium tuberculosis 

  Khan, Haaris Suwaid; 0000-0002-5115-2456 (2020-12-01)

  Mycobacterium tuberculosis (Mtb) can enter the body through multiple routes, including via specialized transcytotic cells called microfold cells (M cell). However, the mechanistic basis for M cell entry remains undefined. ...

• Changes in the Gut Metabolic Landscape Drive Inflammation-Associated Dysbiosis and Host Responses 

  Hughes, Elizabeth Rose; 0000-0003-4967-8819 (2020-12-01)

  Intestinal inflammation is frequently associated with alterations in composition of gut microbial communities, termed dysbiosis. Inflammation-associated dysbiosis is characterized by an expansion of facultative anaerobic ...

• Development of Applications and Quantitative Frameworks for Multispectral Optoacoustic Tomography 

  O'Kelly, Devin Sean; 0000-0003-3082-8338 (2020-12-01)

  The tumor microenvironment is a highly complex system, with variations through space and time that are determined by the interplay of normal and cancerous cells, physiological phenomena, and treatments that can dramatically ...

• Effects of Alcohol Use on Cognition During Later Adulthood 

  Becker, Joshua Eric; 0000-0002-3356-8159 (2020-12-01)

  Alcohol is one of the most widely used psychoactive substance in the world, yet there are conflicting findings related to its long-term effect on cognition. Some research has identified a U-shaped relationship between ...

• Signal Transduction Pathways That Impact Polar Flagellar Biogenesis 

  Burnham, Peter Michael; 0000-0002-0776-3268 (2020-12-01)

  Bacterial flagella are rotating nanomachines required for motility. Flagellar gene expression and protein secretion are coordinated for efficient flagellar biogenesis. Polar flagellates, unlike peritrichous bacteria, ...

• Synthetic Studies of the Rubellin Natural Products 

  Gartman, Jackson Andrew; 0000-0002-3101-403X (2020-12-01)

  The effective construction of complex bioactive molecules often requires the development of innovative chemical methods to push the boundaries of organic synthesis. As the utility of available reactions increases, the ...

• Assessing Approach Motivation in Depressed Individuals with a History of Concussion 

  Cecil, Audrey Lorraine; 0000-0002-2444-6758 (2020-12-01)

  Depression is the leading cause of disability worldwide. Anhedonia, a core symptom of depression, has been described as a lack of pleasure or interest, though it is a much more complex process than simply lack of pleasure. ...

• Evaluation of Social Stories in Sleep Treatment for Children with Autism Spectrum Disorder: A Feasibility Study 

  Israelsen, Lora Jane; 0000-0002-1129-8688 (2020-12-01)

  A majority of children with autism spectrum disorders (ASD) experience sleep disturbances which are apt to negatively impact cognition, behavioral functioning, and the general trajectory of psychosocial development. ...

• Structure and Function of the Alpha3Beta4 Nicotinic Acetylcholine Receptor 

  Gharpure, Anant Vishwanath; 0000-0002-4458-359X (2020-12-01)

  Nicotinic acetylcholine receptors are pentameric ligand-gated ion channels that are essential for the proper function of the central and peripheral nervous systems. The α3β4 subtype is highly expressed in the autonomic ...

• The Functional Roles for SWI/SNF Chromatin Remodeling Complexes in Physiology and Disease 

  Celen, Cemre; 0000-0001-8308-3750 (2020-12-01)

  Sequencing studies have implicated multiple subunits of SWI/SNF complexes in human neurodevelopmental and psychiatric disorders, as well as in cancers. Particularly haploinsufficiency of ARID1B, a SWI/SNF chromatin-remodeling ...

• Improving Protocol Adherence in Central Line Placements 

  Roy, Mathews Francis; 0000-0003-2374-5171 (2022-05-01)

  BACKGROUND: The placement of central lines is a very common exercise in medicine. Central lines are required for everything from acute trauma scenarios to long term cancer treatments. However, this ubiquitous procedure has ...

• Transcription Factor Dynamics Investigated through Single-Molecule Imaging, High-Throughput Sequencing, and Neural Networks 

  Stevens, Evan McAllister; 0000-0003-1515-8305 (2020-08-01)

  Recent chromatin characterization and sequencing technologies, paired with growing power in computational and bioinformatic analysis, have enabled a deeper understanding of the highly sequence-dependent nature of protein-DNA ...

• Characterizing Renal Interstitial Heterogeneity and Its Role in Nephron Patterning 

  England, Alicia Rachel; 0000-0002-1250-1334 (2020-08-01)

  Chronic kidney disease (CKD) is a growing national health concern affecting 30 million Americans. CKD can lead to permanent loss of kidney function requiring treatment for survival, yet the only two treatment options, ...

• Novel Roles for BET Bromodomain Protein 4 (BRD4) in Cardiac Physiology and Disease 

  Kim, Soo Young; 0000-0002-4793-2193 (2020-08-01)

  Bromodomain (BRD) protein of the BET (Bromodomain and Extra-Terminal) family are epigenetic reader proteins that have emerged as novel therapeutic targets in cardiovascular disease as well as in a variety of cancers. Small ...

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