UT Southwestern Electronic Theses and Dissertations
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Welcome to the UT Southwestern Electronic Theses and Dissertations (ETD) community.
Most UT Southwestern ETDs are subject to a default embargo period of two (2) years from the date of degree conferral. These embargoed ETDs are unavailable until the embargo expires.
To verify whether an ETD is available or if you have other questions, please contact etd-utsw@utsouthwestern.edu.
Collections in this community
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UT Southwestern Graduate School of Biomedical Sciences
This collection contains ETDs produced by students of the UT Southwestern Graduate School. -
UT Southwestern Medical School
This collection contains ETDs produced by students of the UT Southwestern Medical School. -
UT Southwestern School of Health Professions
This collection contains ETDs produced by students of the UT Southwestern School of Health Professions (formerly UT Southwestern School of Allied Health Sciences).
Recent Submissions
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Transcriptional Regulation of Intestinal Stem Cell Lineage in Drosophila
(2017-04-17)The question of how somatic stem cells respond to tissue needs is always intriguing, since aberrant somatic stem cell behaviors may lead to adult tissue degeneration or tumorigenesis. Here, this thesis focuses on the ... -
Epidemiology of Burns Treated by Yekatit 12 Burn Unit in 2016
(2017-04-03)BACKGROUND: Burns contribute significantly to the burden of disease, particularly in low and middle-income countries. There is a paucity of data regarding the epidemiology of burns in Ethiopia, and about burn injuries in ... -
Benchmarking Surgical Quality: Cholecystectomy at a Safety-Net Hospital
(2017-04-03)BACKGROUND: Rates of conversion from laparoscopic to open cholecystectomy in the U.S. have been reported to be 5 to 10%. This study aims to benchmark conversion rate and identify preoperative factors that are predictive ... -
Transcriptional and Cytokine Profiles Identify CXCL9 as a Biomarker of Disease Activity in Morphea
(2017-03-31)Interferon-related pathways have not been studied in morphea and biomarkers are needed. We sought to characterize morphea serum cytokine imbalance and interferon-related gene expression in blood and skin to address this ... -
Distinct Functional Phases in Proteins: A Test by Large-Scale Protein Design
(2017-03-24)The biological properties of proteins - folding, biochemical functions, and evolvability - originate from the global pattern of interactions between amino acids. Coevolution studies suggest a model for this pattern in which ... -
Assessment of Dermatology Clinic Resources at Safety-Net Hospitals: Results from a National Survey
(2017-03-24)BACKGROUND: The extent of resources available to outpatient dermatology clinics at safety-net hospitals providing care to the underserved is not well characterized. Identification of resource gaps can direct strategies ... -
Switching the Fate of mRNAs for Mitochondrial Biogenesis
(2017-03-02)mRNAs encoding mitochondrial biogenesis proteins are co-regulated in a manner closely linked to metabolism. In yeast growing in glucose, mitochondrial biogenesis is repressed, but must be induced upon glucose depletion to ... -
Epidemiology of Traumatic Brain Injuries at a Major Government Hospital in Cambodia
(2017-03-02)BACKGROUND: Traumatic brain injury (TBI) is a critical public health problem worldwide with a significant socioeconomic burden. While improved safety regulations in high-income countries have resulted in a decline in ... -
Transcription of the Long Noncoding RNA, UpperHand, Is Required for Heart Development
(2016-10-03)The basic helix-loop-helix transcription factor HAND2 is an ancestral regulator of heart development and one of four cardiac transcription factors that controls the reprogramming of fibroblasts to cardiomyocytes. Genetic ... -
From Feast to Famine: A Tale of Satiety and Hunger Hormones
(2016-04-18)Ghrelin is a peptide hormone secreted mainly from the stomach. It has a unique octanoylation on Ser-3 by Ghrelin-O-Acyltransferase (GOAT). We have previously shown that Goat−/− mice developed severe hypoglycemia under 60% ... -
The Regulation of Flagellar Biosynthesis and Cell Division in Campylobacter jejuni
(2016-04-05)Flagellar biosynthesis is one of the rare processes known to be spatially and numerically regulated in polarly-flagellated bacteria. Polar flagellates must spatially and numerically regulate flagellar biogenesis to create ... -
Effects of Size on Ovoid Anterior Septal Perforations: Physiologic Modeling With Computational Fluid Dynamics
(2016-04-04)BACKGROUND: Nasal septal perforations (NSPs) often cause bleeding, crusting, obstruction, and/or whistling. Exposed cartilage along the perimeter of the perforation prolongs healing time. The perforation perimeter lies in ... -
The Burden of Gunshot Injuries on Orthopaedic Healthcare Resources in South Africa
(2016-04-07)BACKGROUND: Injuries inflicted by gunshot wounds (GSW) are an immense burden on the South African healthcare system. In 2005, Allard et al. estimated South African state hospitals treat approximately 127,000 firearm victims ... -
Gamification of Exercise and Its Application for Fall Prevention Among Patients with Diabetes and Peripheral Neuropathy
(2016-04-04)BACKGROUND: Individuals with diabetic peripheral neuropathy (DPN) often experience concomitant impaired proprioception and postural instability. Diminished peripheral sensory input, as found in DPN, has been associated ... -
Modulating SIRP-alpha, a Myeloid-Specific Immune Checkpoint, for Immunotherapeutic Treatment of Malignancy
(2016-04-01)BACKGROUND: CD47 is a "don't-eat-me" signal upregulated by many types of cancer that signals through its receptor SIRPα to inhibit macrophage-mediated destruction. Recent studies have demonstrated the efficacy of anti-CD47 ... -
Accuracy in Diagnosing Pediatric Appendicitis: Discordance in Diagnosis and Masqueraders
(2016-04-04)BACKGROUND: The classification of perforated versus nonperforated appendicitis remains poorly defined despite being clinically significant and requiring dramatically different therapeutic approaches. We hypothesized that ... -
Isoflurane Preserves Viability of Highly Metabolic Renal Epithelial Cells Exposed to Anoxia
(2016-04-01)BACKGROUND: Cells subjected to ischemia, whether in the context of hypoxia, hypovolemia, or circulatory collapse, undergo damage and death as a result of oxygen deprivation. Previous studies have shown that general anesthetics ... -
Leptospirosis Risk Perception and Associated Behavior in a Region of High Seroprevalence in Iquitos, Peru
(2016-04-01)BACKGROUND: Iquitos has an ideal environment for Leptospira transmission leading up to endemic leptospirosis. Studies in Belen, an urban slum in Iquitos, indicate seroprevalence as high as 28% with rates higher in flooding ... -
Long-Term Management of Luminal Urethral Stricture in Women
(2016-04-01)BACKGROUND: Luminal urethral strictures (LUS), though rare, are very bothersome conditions that can cause significant voiding symptoms and adversely affect women's' quality of life. Urethral dilation (UD) is commonly ... -
Identification of ITGBL1: A Novel Regulator of Adipogenesis
(2016-04-01)BACKGROUND: Obesity is a global epidemic that increases the risk of chronic metabolic disease. The rising burden of human suffering inflicted by the double-edged sword of obesity and diabetes has increased the urgency of ...
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