UT Southwestern Electronic Theses and Dissertations
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Welcome to the UT Southwestern Electronic Theses and Dissertations (ETD) community.
Most UT Southwestern ETDs are subject to a default embargo period of two years from the date of submission. These embargoed ETDs are unavailable until the embargo expires. If you are prompted to select a school to log in or see a message that reads "This item is restricted", then the ETD is still under embargo. It might be possible to contact the author for more information before the end of the embargo through the UT Southwestern Graduate School of Biomedical Sciences, SouthwesternGraduateSchool@utsouthwestern.edu. To verify whether an ETD is available or if you have other questions, please contact etd-utsw@utsouthwestern.edu.
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UT Southwestern Electronic Theses and Dissertations
This collection contains UT Southwestern ETDs.
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Transmembrane Protease TMPRSS11B Promotes Lung Cancer Growth by Enhancing Lactate Export and Glycolytic Metabolism
(2018-11-26)Pathways underlying metabolic reprogramming in cancer remain incompletely understood. We identified the Transmembrane Serine Protease TMPRSS11B as a novel gene that promotes transformation of immortalized human bronchial ... -
Regulation and Dysregulation via Docking Interactions in WNK and ERK1/2 MAPK Signaling
(2016-12-07)Protein-protein interactions are essential for nearly every cellular process. Within signaling pathways, such interactions carry out numerous functions such as defining substrate specificity, inhibition of both other ... -
A Reverse Translation Mouse Model for Schizophrenic Psychosis: Contribution of Hippocampal Subfield Pathology
(2016-11-30)Schizophrenia is a serious and lifelong psychotic illness that affects all aspects of cognitive and affective function and whose etiology and brain mechanisms remain elusive. Schizophrenia affects not only those who express ... -
Transcriptional Mechanisms Underlying Neuronal Activity-Dependent Plasticity
(2016-11-21)Impairment in learning and memory is a well-established cognitive symptom that is manifested in many psychiatric diseases including autism and schizophrenia. Studies have shown that long-lasting memory formation is mediated ... -
BMP Signaling Regulates Germ Cell Pluripotency, Sexual Differentiation, and Cancer Susceptibility
(2016-10-14)Testicular germ cell tumors are the most common malignancy found in young men between the ages of 14-40. While these tumors are highly curable with cisplatin based combined chemotherapies, the treatments come with very ... -
Spontaneous Neurotransmission as a Driver of Calcium Signaling
(2016-09-20)Spontaneous neurotransmission is a stochastic mode of neurotransmitter release that is not coupled to action potential arrival at the presynapse. Recent evidence has shed light upon the presynaptic and vesicular fusion ... -
Hippocampal Subfield Transcriptome Analysis in Schizophrenia Psychosis
(2018-11-29)Schizophrenia is one of the thirty most incapacitating conditions in the world and affects tens of millions of people worldwide. Devastatingly, suicide occurs in 10% of those diagnosed with schizophrenia. Symptoms are ... -
Tale of Two Hosts: Vibrio parahaemolyticus Toxicity Against Human and Shrimp
(2016-11-17)Bile is an important component of the human gastrointestinal tract with an essential role in food absorption and antimicrobial activities. Enteric bacterial pathogens have developed strategies to sense bile as an environmental ... -
Identification and Characterization of Drug Targets in the Pyrimidine and Purine Pathways of Trypanosoma brucei
(2016-11-29)The single-celled extracellular parasite Trypanosoma brucei causes Human African Trypanosomiasis (HAT), which is fatal if untreated. Current therapies result in severe side effects and require complex treatment regimens. ... -
Safeguard of Mitosis: The Spindle Checkpoint
(2016-11-18)In mitosis, the kinetochore-microtubule attachment is under surveillance by the spindle checkpoint to ensure the fidelity of chromosome segregation. Defects in the checkpoint could lead to aneuploidy, which has been ... -
Regulation of the Tumor Suppressor ARF by TGFβ in Human Cancer Cells
(2016-11-29)Since its discovery, p14ARF (p19Arf in mice) has been shown to be an important regulator of the cell cycle, carrying out this function through p53-dependent and independent mechanisms. ARF expression has recently been shown ... -
Epigenetic Regulation of Oligodendrocyte Development and Regeneration in the Central Nervous System
(2016-10-26)Oligodendrocytes (OLs) produce myelin sheaths that electrically insulate axons and promote rapid propagation of action potentials in the CNS. The onset and timing of CNS myelination and remyelination requires precise ... -
Mechanistic Analysis of Microtubule Dynamics and Regulation
(2018-10-15)Microtubules are critical components in a cells cytoskeletal network, known to form the mitotic spindle which allows for chromosome segregation and cell division and organizing the cytoplasm of non-dividing cells. The ... -
Context-Selective Support of the AKT/mTOR Regulatory Axis by Tank-Binding Kinase 1 (TBK1)
(2016-11-28)Oncogenic mutation of Ras or Ras effector signaling characterizes roughly thirty percent of all cancers. Persistent obstacles to the treatment of these diseases by direct Ras inhibition prompt alternative strategies aimed ... -
Mechanisms of Synapse Depression in Response to Postsynaptic Patterned Burst Firing
(2016-11-28)Neuronal activity and experience stimulate synapse pruning (Zuo et al 2005b) to refine neuronal circuits during early postnatal development (Hua & Smith 2004), and are critical for learning and memory (Fu & Zuo 2011). ... -
A Biopsychosocial Model of Attachment Styles and Adverse Birth Outcomes in High-Risk Pregnancies
(2016-04-13)Because stress during pregnancy can contribute to preterm birth, low birth weight, and other adverse birth outcomes, there is a need for research on psychosocial factors that may mitigate this risk. Social support and ... -
Intrinsic Specificity of Binding and Regulatory Function of Class II bHLH Transcription Factors
(2016-11-28)Embryonic development begins with a single cell, and gives rise to the many diverse cells which comprise the complex structures of the adult animal. Distinct cell fates require precise regulation to develop and maintain ... -
The Role of NeuroD1 in Physiological and Pathological Neurogenesis
(2016-12-05)Neurogenesis in the adult brain is a complex and highly regulated process. Under normal physiological conditions neurogenesis in the hippocampal subgranular zone (SGZ) is important for learning, memory, and mood regulation. ... -
Synthetic Studies in the Selective Functionalization of Unsaturated Compounds: From Initial Applications in Medicinal Chemistry to General Applications in Unactivated Systems
(2016-09-16)Medicinal chemistry and reaction development have influenced one another in the field of organic chemistry. The synthesis of therapeutic small molecules often requires the use of practical synthetic methodologies, while ... -
Regulation of Blood Vessel Development via Rho Family GTPase Signaling
(2016-11-28)The Rho family of small GTPases has been shown to be required in endothelial cells (ECs) during blood vessel formation. However, the underlying cellular events controlled by different GTPases remain unclear. Here, we assess ...
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