UT Southwestern Electronic Theses and Dissertations
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Welcome to the UT Southwestern Electronic Theses and Dissertations (ETD) community.
Most UT Southwestern ETDs are subject to a default embargo period of two years from the date of submission. These embargoed ETDs are unavailable until the embargo expires. If you are prompted to select a school to log in or see a message that reads "This item is restricted", then the ETD is still under embargo. It might be possible to contact the author for more information before the end of the embargo through the UT Southwestern Graduate School of Biomedical Sciences, SouthwesternGraduateSchool@utsouthwestern.edu. To verify whether an ETD is available or if you have other questions, please contact etd-utsw@utsouthwestern.edu.
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UT Southwestern Electronic Theses and Dissertations
This collection contains UT Southwestern ETDs.
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Targeting Glutamine Metabolism in Kidney Development and Polycystic Kidney Disease
(2018-07-30)Polycystic kidney disease is a hereditary disorder characterized by the progressive manifestation of numerous fluid-filled sacs, known as cysts, within the renal epithelia. The enlargement of the cysts causes the gradual ... -
Endolysosomal Function in Neuronal Maintenance
(2018-06-14)Endolysosomal degradation of membrane proteins is crucial for the maintenance of synaptic function and neuronal health. Neurons can live for the lifetime of an organism and therefore rely on robust membrane turnover ... -
The Role of MEF2 Transcription Factors in Neocortical Circuit and Synapse Development In Vivo
(2016-08-10)Proper neocortical circuit development requires postnatal experience and transcription. Neocortical neurons migrate to their proper layers and then undergo robust synapse proliferation to maximize contacts with presynaptic ... -
Clinical Diagnostic Potential and Characterization of Distinctly Hypermutated Antibodies in Multiple Sclerosis Patients
(2016-08-12)Multiple sclerosis (MS) diagnosis primarily revolves around the use of brain lesion detection by MRI and the elimination of other possible neurological disorder diagnoses through clinical testing and history. For many ... -
Engagement in Care among Patients with Lung Cancer
(2016-07-29)BACKGROUND: Engagement in care broadly refers to patients' knowledge, skills, ability and willingness to play an active role in their health. Patient activation is a core component of engagement and has been associated ... -
Examining the Role of PRDM13 in Dorsal Interneuron Specification
(2016-07-29)PTF1A is a transcription factor transiently expressed as neural progenitor cells become post-mitotic and begin to express neuronal specific genes. PTF1A specifies these cells to become GABAergic (inhibitory) neurons while ... -
Mechanisms of Genome Buffering and Cell Fate Coordination in Adult Tissue Homeostasis
(2016-07-26)Self-renewal competency of adult stem cells is essential for tissue homeostasis. The corruption of genes essential for genome preservation or for niche-stem cell interactions frequently results in loss of stem cell viability ... -
Characterization of Non-Coding RNAs in Regulating Thymic Epithelial Cell Responses to Pathophysiological Stress
(2016-07-26)The thymus is uniquely sensitive to several forms of stress. Stress initiates a transient involution that can reduce overall thymic volume up to 90%. The thymus is predominantly composed of developing thymocytes and ... -
Novel Insights into DNA Double-Strand Break Repair and Its Cancer Implications
(2016-07-27)Despite the aggressive treatment with DNA damage-inducing agents, glioblastomas (GBM) inevitably develop therapy resistance, leading to relapse and patient mortality. Cancer cells that survive therapy acquire additional ... -
Self-Reported Head Injury: Associated Risk in Mild Cognitive Impairment and Progression to Alzheimer Disease
(2016-07-27)Traumatic brain injury (TBI) has been associated with a higher risk for and earlier onset of neurodegenerative disorders, including Alzheimer disease (AD), but its mechanistic link is not well understood. TBI has been ... -
Effectiveness of Interdisciplinary Pain Management Programs in Elderly Populations
(2016-07-25)BACKGROUND: Chronic pain is a debilitating disease that affects millions of adults in the United States. In recent years, there has been a steady increase in the use of interdisciplinary interventions to treat chronic pain. ... -
Psychological Factors in Neurogenic Thoracic Outlet Syndrome: Resilience and Post-Surgical Quality of Life
(2016-07-25)Neurogenic thoracic outlet syndrome (nTOS) is a complex condition caused by compression of neurovascular structures in the thoracic outlet and is often associated with chronic pain and disability. Surgical management of ... -
Nocturnin Regulates Metabolic Flux Through Maintenance of Poly(A) Tail Length Dynamics
(2016-07-26)Cyclic processes in both behavior and physiology are aligned to the external environment through the circadian clock. Nocturnin (Noc) is a rhythmically expressed gene regulated in part by the circadian clock and intimately ... -
Fibulin-5 Promotes Pancreatic Tumor Growth through Inhibition of Integrin-induced ROS: Insights into Tumor-Matrix Signaling
(2016-07-18)Elevated oxidative stress is an aberration seen in many solid tumors, and exploiting this biochemical difference has the potential to enhance the efficacy of anti-cancer agents. Homeostasis of reactive oxygen species (ROS) ... -
Use of Regional Brain Volume, the Montreal Cognitive Assessment, and Self-Reported Cognitive Complaint to Predict Future Cognition
(2016-07-18)Early and accurate prediction of future cognitive impairment can promote increased use of interventions, which in turn can lead to delayed decline and therefore higher quality and potentially longer length of life. There ... -
Small Molecules Modulate Chromatin Accessibility to Promote NEUROG2-Mediated Fibroblast-to-Neuron Reprogramming
(2016-07-12)The activity of pro-neural signaling molecules and transcription factors is sufficient to induce the transdifferentiation of lineage-restricted fibroblasts into functional neurons; however, a mechanistic model of the ... -
The Interpersonal Theory of Suicide among Adolescents: Examining the Theory over the Course of Treatment
(2016-07-29)Suicide is a one of the leading causes of death among young adults and adolescents. Adolescence is the period where suicidal phenomena typically develop and may offer an important window for understanding suicidal behavior. ... -
Biomarker Accessible and Chemically Addressable Mechanistic Subtypes of BRAF Melanoma
(2016-06-23)Genomic diversity and adaptive plasticity of melanoma tumors limit durable control with conventional and targeted therapies. Nevertheless, pathological activation of the ERK1/2 regulatory system is a linchpin tumorigenic ... -
HP1BP3, A Chromatin Retention Factor for Co-Transcriptional MicroRNA Processing
(2016-06-27)RNA interference (RNAi) is a post-transcriptional gene silencing mechanism found in all eukaryotic organisms. It is characterized by a family of small non-coding RNAs, either endogenous (in the case of microRNAs) or exogenous ... -
Family Studies of Sensorimotor Disturbances in Autism Spectrum Disorder
(2016-07-26)Sensorimotor impairments are prevalent in individuals with autism spectrum disorder (ASD) and among the earliest emerging features, yet the pathophysiological mechanisms underlying these deficits remain poorly understood. ...
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