Browsing UT Southwestern Electronic Theses and Dissertations by Title
Now showing items 1-20 of 1619
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1,3-Dipolar Cycloaddition of Electron-rich Alkynes and Optically Active Allenes in Asymmetric Catalysis
(2009-09-04)This dissertation includes two parts. The first part focuses on two 1,3-dipolar cycloadditions of electron-rich alkynes. Chapter one describes a copper-promoted cycloaddition reaction of acetylides with diazocarbonyl ... -
3 Tesla Magnetic Resonance Imaging of Hippocampal Asymmetry: Results from the Dallas Heart Study
(2013-06-01)BACKGROUND: Asymmetry of the hippocampus is regarded as an important clinical finding but limited data on hippocampal asymmetry is available for the general population. Here we present hippocampal asymmetry data from the ... -
[3+2]-Cycloadditions of Azomethine Imines and Ynolates and Progress Towards a Radical Three-Component Cross-Coupling Reaction
(2018-07-16)This manuscript consists of three chapters. The first chapter describes a novel [3+2]-cycloaddition of azomethine imines and ynolates to construct bicyclic pyrazolidinones in high yields and diastereoselectivities. This ... -
3D Animated Video Series for Patient Education of Pelvic Organ Prolapse and Sacrocolpopexy Surgery
(2012-12-20)The objective of this video series was to present a comprehensive three-dimensional patient education video series that described basic female pelvic anatomy, types of pelvic organ prolapse, basic procedural steps for a ... -
4D Study of Thoracic Cancer Radiation Treatment
(2007-05-22)Respiratory motion causes an added uncertainty in the radiation treatment of thoracic malignancies due to an increase in the normal tissue irradiated and an uncertainty in the radiation coverage of the tumor. This results ... -
Abbreviated and Expanded Forms of the Montreal Cognitive Assessment for Dementia Screening
(2015-07-15)Cognitive screening is becoming increasingly important as the general population ages and the prevalence of dementia rises. However, popular cognitive screening tools have been criticized for their insensitivity to subtle ... -
Aberrant DNA Methylation and Cancer: A Global Analysis of Promoter Hypermethylation in Human Lung Cancers
(2006-12-20)Tumor-acquired alterations in DNA methylation include both genome-wide hypomethylation and locus specific hypermethylation. Global loss of DNA methylation destabilizes chromatin architecture, augments genomic instability, ... -
Ability of the Pain Disability Questionnaire in Predicting Healthcare Utilization
(2014-09-01)BACKGROUND: Chronic pain is one of the most expensive and prevalent healthcare problems in the United States. It affects not only the individual but also society as a whole. The Biopsychosocial Model of chronic pain is ... -
Acanthamoeba spp. Secrete a Mannose-Induced Protein that Correlates with Ability to Cause Acanthamoeba Keratitis
(2004-01-14)Acanthamoeba spp. are ubiquitously distributed in the environment. The trophozoite form can infect the cornea and cause sight-threatening corneal inflammation known as Acanthamoeba keratitis. The pathogenic cascade of ... -
Access to Care Factors Connected to Age at Evaluation for Children Assessed for Autism Spectrum Disorders
(2012-07-20)The early identification of children with an autism spectrum disorder (ASD) is important for intervention programs to take place. The goal of this study was to examine the combination of several sociodemographic factors ... -
Accuracy in Diagnosing Pediatric Appendicitis: Discordance in Diagnosis and Masqueraders
(2016-04-04)BACKGROUND: The classification of perforated versus nonperforated appendicitis remains poorly defined despite being clinically significant and requiring dramatically different therapeutic approaches. We hypothesized that ... -
Acetaminophen Dose Does Not Predict Outcome in Acetaminophen-Induced Acute Liver Failure
(2010-04-09)Acetaminophen is a dose-dependent toxin. Prognosis in severe acute liver injury is related presumably in part to the dose ingested. We sought to assess the value of acetaminophen dosing information in patients with acute ... -
Acres of Diamonds: Rediscovering Community Assets in Dallas Backyards
(2016-04-01)BACKGROUND: Diabetes directly affects 8% of the US population and poses a growing burden to healthcare providers, to the health system, and to society. Cultivating self-efficacy enhances personal agency and enables patients ... -
Actin Regulatory Dynamics Required for T Cell Activation: A Quantitative and Systems-Level Perspective
(2013-02-04)T cell activation occurs through interaction with an antigen-presenting cell (APC). Upon activation, signaling ensues with the coordination of dozens of diverse signaling molecules in space and time, a feature of cell ... -
Activated RhoA Positively Regulates Exchange Activity of PDZ-RhoGEF
(2012-12-06)RhoA plays a key role in regulation of the actin cytoskeleton, cell migration and cell shape. Rho GTPases cycle between an inactive GDP-bound state and an active GTP-bound state. This cycle is mediated by guanine nucleotide ... -
Activation of Early Neural Progenitors Is Required for Traumatic Brain Injury-Induced Hippocampal Neurogenesis
(2008-09-19)Traumatic brain injury (TBI) is the most common form of acquired brain injury in both children and adults in the United States. TBI causes neuronal loss and results in a variety of neurological impairments and deficits ... -
Activity-Dependent Regulation of Inhibition from Different Inhibitory Subtypes
(2007-08-08)Neuronal activity, in the form of action potential firing, is critical in the maturation and maintenance of neocortical circuitry. A negative feedback mechanism by which neuronal circuits adapt to changing levels of average ... -
Acute Treatment Outcomes and Family Functioning of Children and Adolescents Diagnosed with Anorexia Nervosa
(2006-08-11)Recent studies have suggested that there is a relationship between treatment outcomes and baseline factors related to family functioning and specific eating disorder symptoms. However, these relationships have not been ... -
Acyloxyacyl Hydrolase: Studies on Its Regulation and Function in Mus Musculus
(2004-01-14)Acyloxyacyl hydrolase (AOAH) is an enzyme that detoxifies Gram-negative bacterial lipopolysaccharides (LPS) by selectively removing secondary acyl chains from the lipid A moiety. Originally found in neutrophils, it is also ... -
The Addicted Phenotype: Protein Phosphorylation Status and Dopamine Receptor Responsiveness
(2007-05-22)Up-regulation of cAMP/PKA signaling by drugs of abuse may contribute to escalation and relapse, possibly by differentially altering dopamine receptor-responsiveness in the mesolimbic dopamine system. To investigate this ...