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Uncovering the Complexity of RAS Signaling Networks
The Raf/MEK/MAP Kinase signal transduction cascade is a key Ras effector pathway that mediates diverse cellular responses to environmental cues, and makes a major contribution to Ras-dependent oncogenic transformation. ...
The Role of the Scaffolding Protein INAD in Localization of Signaling Complexes to the Rhabdomeres of Drosophil Photoreceptors
Organization of proteins into macromolecular complexes is one way cells maximize the speed, specificity, and efficiency of signal transduction. In fruit fly photoreceptors InaD, a scaffolding protein containing 5 PDZ ...
Scaffold-Mediated Organization of Signal Transduction Networks
The Raf-MEK-ERK kinase cascade is a highly conserved signal transduction module involved in cellular processes ranging from proliferation and differentiation to transformation and apoptosis, and is engaged in response to ...
Design of a Website and Signaling Map Template Acting as a Database Interface and Providing a Visual Explanation of Cellular Signaling Networks an Their Operative Components
The intention of this thesis is to document and describe the design of a website and signaling map template wherein the maps are standardized, expandable in detail, and act as a database interface while providing a visual ...
CDC14 Coordinates Cyclin Destruction with the Onset of Cytokinesis
The Cdc14 family of protein phosphatases operate during the final stages of mitosis in various organisms. The Cdc14 phosphatases are downstream components of two homologous signaling pathways: the mitotic exit network (MEN) ...