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Type I Interferon Mediates Th2 Reprogramming and Acute Suppression of Effector Functions
The type I interferon (IFN-α/β) family is a pleiotropic set of cytokines that play a role in regulating many biological functions, including suppressing viral replication and modulating adaptive immune functions. Although ...
Dual Mechanisms Regulating Alpha Subunit-Specific Activity in Hypoxia-Inducible Factor Signaling
The ability to adapt to and protect from environmental stresses is essential to survival and has played a major role in fitness selection during evolution. As oxygen is essential to most life, many organisms have developed ...
Kinetics and Regulation of Protein Kinases
One of the major functions of kinases in biological systems is the relay of signal from an effector to a downstream target. Kinases are regulated by a diversity of mechanisms, both internal and external to the kinase. When ...