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Biophysical and Biochemical Characterization of a REC Domain: Unfolded to Folded Transition of EL_LovR
Prokaryotes frequently use two component systems to couple environmental stimuli to adaptive responses. These pathways use histidine kinases to detect environmental cues, harnessing these to control phosphorylation of the ...
Signaling Specificity in a Campylobacter jejuni Two-Component System to Mediate Proper Flagellar Gene Transcription
Campylobacter jejuni is a worldwide leading cause of bacterial gastroenteritis. While infection of humans leads to diarrheal disease, C. jejuni asymptomatically colonizes the intestinal tract of many agriculturally-significant ...
Structural and Kinetic Characterization of Protein Ampylation by VopS Fic Domain
The bacterial pathogen Vibrio parahaemolyticus manipulates host signaling pathways by injecting type III effectors into the cytoplasm of the target cell. One of these effectors, VopS, blocks actin assembly by AMPylating a ...
Biochemical Characterization of the Yersinia Effector Protein, YopJ
Yersinia species, the causal agent of plague and gastroenteritis, uses a variety of type III effector proteins to target eukaryotic signaling systems. The effector YopJ disrupts the mitogen-activated protein kinase and the ...