Now showing items 51-55 of 55
Identification and Characterization of a Bacterial Catalytic Scaffold with Specificity for Host Endomembrane Traffic
The fidelity and specificity of information flow within a cell is controlled by scaffolding proteins that assemble and link enzymes into signaling circuits. These circuits can be inhibited by bacterial effector proteins ...
Modulation of CD8+ T Cell Function by Beta2-Adrenergic Receptor Signaling
There is intimate crosstalk between the nervous system and the immune system. The nervous system can respond to immune system cues through afferent nerve endings. One effect of this response is the secretion of neurotransmitters ...
Dynamic Modulation of Exocyst Interaction Networks Integrates Hippo and mTOR Pathway Response to Pathogen Detection
Monomeric RALGTPases, via direct binding to the exocyst (a.k.a Sec6/8 complex), help mount productive cell autonomous responses to trophic and immunogenic signals. However, RAL-exocyst downstream effectors register in a ...
Identifying Novel Functions of the WNK Pathway
The with no lysine [K] (WNK) pathway consists of WNK kinases, their downstream target kinases, oxidative stress responsive (OSR)1 and SPS/Ste20-related proline-alanine-rich kinase (SPAK), and OSR1/SPAK substrates, cation ...
Sympathetic Neural Control of Inflammation by ADRB2-Mediated IL-10 Secretion
The nervous and immune systems reciprocally regulate their functions through the release of chemical messengers. Norepinephrine (NE), a neurotransmitter released by catecholaminergic nerve endings, allows the sympathetic ...