Now showing items 1-3 of 3
Insig-Mediated Regulation of Hepatic Lipid Synthesis
Cholesterol synthesis in mammals is tightly regulated by end-product feedback inhibition. 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) catalyzes a rate determining reaction that is highly regulated by transcriptional ...
Evolutionary Constraints Specifying Protein Folding and Function
Proteins are complex macromolecules that carry out biological functions while under constant mutational load and selective pressure during evolution. Consequently, evolution has generated protein families by exploring the ...
SCAP, Insig, and Cholesterol Interactions in Mammalian Cells
Cholesterol synthesis in mammalian cells is highly regulated by an end-product feedback mechanism. The transcription of genes necessary for both fatty acid and cholesterol production are controlled by sterol regulatory ...