Now showing items 1-4 of 4
Bcl-2 Function in Drosophila
Bcl-2 family members are pivotal regulators of programmed cell death (PCD). In mammals, pro-apoptotic Bcl-2 family members initiate early apoptotic signals by causing the release of cytochrome c from the mitochondria, a ...
SCAP, Insig, and Cholesterol Interactions in Mammalian Cells
Cholesterol synthesis in mammalian cells is highly regulated by an end-product feedback mechanism. The transcription of genes necessary for both fatty acid and cholesterol production are controlled by sterol regulatory ...
Synaptic Cell Adhesion And Functional Architecture Of CNS Synapses
Synapses are specialized intercellular junctions through which neurons communicate. The two sides of a synapse are held together with adhesion molecules. We investigated the role of synaptic adhesion molecules neuroligins, ...
Elucidation of Molecular Mechanisms Underlying Regulation of Cholesterol Synthesis
Insig-1 and Insig-2, a pair of ER membrane proteins, mediate feedback control of cholesterol synthesis through their sterol-dependent binding to two polytopic ER membrane proteins: SCAP and HMG CoA reductase. Sterol-induced ...