Now showing items 1-3 of 3
Structural and Functional Studies of the Munc13 MUN Domain and the RIM C2B Domain
Neurotransmitter release is essential for normal brain function and is achieved through exocytosis of synaptic vesicles. Many proteins are involved the regulation of neurotransmission. The central fusion machinery includes ...
Structural and Functional Studies of C2-Domain Proteins Involved In Neurotransmitter Release
Neurotransmitter release is mediated by synaptic vesicle exocytosis at presynaptic nerve terminals. This process is extremely fast and strictly regulated by the intracellular Ca2+ concentration. To achieve this exquisite ...
Regulation and Lineage Analysis of Neurog1 in the Developing Spinal Cord
The bHLH transcription factor Neurog1 is involved in neuronal differentiation and cell-type specification in distinct regions of the developing nervous system. I developed mouse models that efficiently drive expression ...