Now showing items 1-4 of 4
Protein Phosphatase Inhibitor-1 and Cdk5: Of Molecules and Memory
Protein phosphatase inhibitor-1 and cyclin-dependent kinase 5 (Cdk5) have been independently implicated in synaptic plasticity, learning, and memory. We began our studies with the identification, confirmation, and ...
Control of the Interferon Regulatory Factor - 3 Antiviral Pathway by The Hepatitis C Virus Ns3/4a Protease
Hepatitis C Virus (HCV) is a major human pathogen that affects 200 million people worldwide. A majority of people exposed to HCV become chronically infected. In order to persist, the virus must encode mechanisms to subvert ...
Revealing Regulation and Organization of Signaling Networks by Scaffolding Proteins
Understanding the molecular mechanism that controls how cells respond to their environment is of major biological significance. The RAS/RAF signal transduction pathway is a good model with which to investigate this question ...
Biochemical Characterization of the Yersinia Effector Protein, YopJ
Yersinia species, the causal agent of plague and gastroenteritis, uses a variety of type III effector proteins to target eukaryotic signaling systems. The effector YopJ disrupts the mitogen-activated protein kinase and the ...