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MEF2 and HDAC Proteins Regulate Striated Muscle Development and Remodeling
The establishment of different tissues during embryogenesis requires coupling of upstream signal transduction pathways with networks of transcription factors that govern cell differentiation and morphogenesis. The myocyte ...
Insig-Mediated Regulation of Hepatic Lipid Synthesis
Cholesterol synthesis in mammals is tightly regulated by end-product feedback inhibition. 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) catalyzes a rate determining reaction that is highly regulated by transcriptional ...
The Roles of Forkhead Transcription Factors in Stem Cell and Myogensis
Vertebrate myogenesis is a highly conserved process that involves the formation, activation, proliferation, and overall regulation of myogenic progenitor cells (MPCs) that are essential for muscle formation, growth, and ...
Spatial-Temporal Regulation of the Atonal Homolog 1 Gene
Controlled spatio-temporal expression of atonal homolog 1 is necessary for the correct development of the cerebellar granule cells, the dorsal interneuron 1 population, gut goblet cells and the cochlear and vestibular hair ...