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Safeguard of Mitosis: The Spindle Checkpoint
In mitosis, the kinetochore-microtubule attachment is under surveillance by the spindle checkpoint to ensure the fidelity of chromosome segregation. Defects in the checkpoint could lead to aneuploidy, which has been ...
Regulation and Mechanism of Bub1-Mediated Spindle Checkpoint Signaling
The spindle checkpoint is a surveillance mechanism that ensures the fidelity of chromosome segregation during mitosis and meiosis. Bub1 is a highly conserved protein serine/threonine kinase that plays multiple roles in the ...
The Multifunctional Kinase Bub1 Acts as a Signaling Hub for the Spindle Checkpoint
The spindle checkpoint is an essential mechanism to ensure accurate chromosome segregation during mitosis. The checkpoint signal originates from the kinetochore, which is a huge protein assembly on centromeric chromatin. ...