Now showing items 1-4 of 4
Structural Analysis of STE20-Related Proline-Alanine-Rich Kinase (SPAK)
Ste20-related proline-alanine-rich kinase (SPAK) is a kinase that regulates ion cotransporters including KCC, NKCC1, NKCC2 and NCC. Recently, SPAK was identified as a target regulated by the WNK (With No lysine (K)) family ...
Characterizing New Molecules and Mechanisms of Semaphorin/Plexin/MICAL Signaling
The mechanisms that regulate the cellular behaviors including morphology, motility, navigation, and connectivity that are critical for normal human health are still incompletely understood. These types of behaviors are ...
With No Lysine (WNK) Family Proteins and Their Interaction with Downstream Kinases
With no lysine (WNK) kinases are a family of protein kinases characterized by unusual kinase domain architecture. These large proteins, divergent outside of a kinase core and protein-protein interaction motifs, have been ...
Regulation and Dysregulation via Docking Interactions in WNK and ERK1/2 MAPK Signaling
Protein-protein interactions are essential for nearly every cellular process. Within signaling pathways, such interactions carry out numerous functions such as defining substrate specificity, inhibition of both other ...