Now showing items 1-3 of 3
B-Cell Adapter for Phosphoinositide 3-Kinase Is a Signaling Adapter in the Toll-Like Receptor/Interleukin-1 Receptor Superfamily
Toll-like receptor (TLR)/Interleukin-1 receptor (IL1R) superfamily members share signaling components and (with the exception of TLR3) depend on the adapter myeloid differentiation primary response gene 88 (MyD88) for ...
Key Roles of Ubiquitination and Phosphorylation in RIG-I/MAVS Viral Sensing Pathway
RNA virus infections are detected by the RIG-I family of receptors, which induce the production of type-I interferons (IFNs) and other antiviral molecules through the mitochondrial membrane protein MAVS. We have recently ...
Biochemical Dissection of Innate Immune Signaling Mechanisms Mediated by MAVS and Inflammasomes
Project 1: MAVS Recruits Multiple Ubiquitin E3 Ligases to Activate Antiviral Signaling Cascades The RIG-I antiviral pathway plays a pivotal role in innate immune response against RNA viruses. Upon virus infection, viral ...