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Uncovering the Complexity of RAS Signaling Networks
The Raf/MEK/MAP Kinase signal transduction cascade is a key Ras effector pathway that mediates diverse cellular responses to environmental cues, and makes a major contribution to Ras-dependent oncogenic transformation. ...
Scaffold-Mediated Organization of Signal Transduction Networks
The Raf-MEK-ERK kinase cascade is a highly conserved signal transduction module involved in cellular processes ranging from proliferation and differentiation to transformation and apoptosis, and is engaged in response to ...