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Wnt9b Signals Through Two Distinct Pathways to Regulate Progenitor Maintenance, Differentiation and Morphogenesis During Kidney Development
The development of the kidney is dependent upon reciprocal interactions between the ureteric bud epithelium and a mesenchymal progenitor population known as the metanephric mesenchyme. Signals from the ureteric bud cause ...
Functional Genomics Based Interrogation of Cell-Fate Determination Pathways
The Hedgehog (Hh) and Wnt signal transduction pathways are master regulators of embryogenesis and tissue renewal and represent anticancer therapeutic targets. Using genome-wide RNA interference screening in murine cultured ...
Mechanisms of Genome Buffering and Cell Fate Coordination in Adult Tissue Homeostasis
Self-renewal competency of adult stem cells is essential for tissue homeostasis. The corruption of genes essential for genome preservation or for niche-stem cell interactions frequently results in loss of stem cell viability ...
Quantitative Single-Cell Imaging Reveals Insulation of Morphogenic Signal Transduction
How cells integrate external cues in order to make behavioral decisions is a central problem of cell biology. In development and in tissue-homeostasis, cell-fate decisions are made by the integration of multiple morphogenic ...