UT Southwestern Graduate School of Biomedical Sciences
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Welcome to the UT Southwestern Graduate School of Biomedical Sciences’ electronic theses and dissertations (ETD) collection.
Most UT Southwestern ETDs are subject to a default embargo period of two (2) years from the date of degree conferral. These embargoed ETDs are unavailable until the embargo expires.
It might be possible to contact the author for more information before the end of the embargo. For assistance or more information, please contact the UT Southwestern Graduate School of Biomedical Sciences by email.
To verify whether an ETD is available or if you have other questions, please contact etd-utsw@utsouthwestern.edu.
Recent Submissions
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Exploiting Evolutionary Tradeoffs to Fight Evolution of Antibiotic Resistance
(2019-08-02)Evolution of antibiotic resistance is a growing public health problem around the world, and the identification of novel antimicrobials is no longer a viable approach to tackling this problem. To design smart technologies ... -
Brain-Region-Specific Contributions of FOXP1 to Autism and Intellectual Disability Phenotypes
(2017-08-11)Mutations and deletions in the transcription factor FOXP1 are causative for severe forms of autism spectrum disorder (ASD) that are often comorbid with intellectual disability (ID). FOXP1 is enriched throughout the brain, ... -
Molecular Regulation of Direct Cardiac Reprogramming
(2017-08-14)A heart attack (also known as myocardial infarction, MI) happens when the flow of blood to the heart is blocked. A massive heart attack can kill billions of cardiomyocytes. The heart has limited regenerative potential ... -
The Role of HNF4A in Germ Cell Tumor Development
(2017-08-10)Yolk sac tumor is a histological category of germ cell tumors, which represent the most frequent malignancy in young men. Little is known about the molecular mechanisms responsible for the aberrant differentiation and ... -
Localization and Function of Bacterial Type III and IV Effector Proteins
(2017-07-31)Eukaryotic cell signal transduction networks are highly dynamic and complex systems largely composed of signaling enzymes with modular protein interaction domains and subcellular localization motifs. These sophisticated ... -
Mechanistic Analysis of Radiation-Induced Gliomagenesis
(2017-07-28)Glioblastomas (GBM) are devastating brain tumors refractory to any available treatment. Exposure to ionizing radiation (IR) is the only known GBM risk factor. The link between low-linear energy transfer (LET) IR and ... -
Emotion Dysregulation and the Interpersonal Theory of Suicide in Adolescents
(2017-07-28)The lack of progress in suicide prevention has been attributed to fractured investigations of disparate risk factors and inadequate theoretical frameworks. Adolescents are different from adults in ways that are likely to ... -
Longitudinal Analysis of Changes in Facial Asymmetry and Quality of Life in Patients with Cleft Lip and/or Palate
(2017-07-28)Previous research has suggested that youth diagnosed with cleft lip and/or palate (CL/P) with more visible facial differences may report lower quality of life than those with less visible facial differences. Three-dimensional ... -
Insights into the Metabolic Regulation by GATOR1 in Response to Amino Acid Signaling
(2017-07-27)The GATOR1/SEACIT complex consisting of Iml1-Npr2-Npr3 inhibits Target of Rapamycin Complex 1 (TORC1) in response to amino acid insufficiency. In glucose medium, yeast mutants lacking the function of this complex grow ... -
Use of a Pre-Employment Multitasking Instrument and Neuropsychological Measures to Predict Field Performance in Police Officers
(2017-07-27)The role of the police officer has evolved drastically since the inception of pre-employment psychological evaluations in the 1960s and increasingly relies on adequate multitasking ability to keep up with the demands of ... -
Congruence of Parent-Report, Self-Report, and Performance-Based Neuropsychological Functioning in Pediatric Acute Lymphoblastic Leukemia Survivors
(2017-07-28)Acute Lymphoblastic Leukemia (ALL) is thought to have long-term cognitive effects, and clinicians often rely on parent report to screen for cognitive impairment during survivorship, despite limited congruence with ... -
Architecture of the Mammalian Circadian Repressive Complex
(2017-07-27)Intricate timing systems have evolved to help organisms in all walks of life organize their physiology to the solar day. Mammalian circadian clocks are driven by a transcription/translation feedback loop composed of positive ... -
Cognitive Processing Therapy and Trauma-Related Negative Cognitions: Relationship and Effect on Treatment
(2017-07-27)Cognitive Processing Therapy (CPT) is based on the theory that posttraumatic stress disorder (PTSD) is a disorder of non-recovery after an exposure to a qualifying trauma. This non-recovery results in assimilated and ... -
In Vivo Genome-Wide Analyses of the Drosophila p53 Transcriptional Network
(2017-07-27)p53 is the most commonly mutated gene in human cancers. Despite decades of p53 studies we do not fully understand how p53 suppresses tumors. Similar to human p53, the Drosophila counterpart is a transcription factor that ... -
The Role of Mindfulness, Attachment, and Stress in Diverse Populations During Pregnancy
(2017-07-27)As stress can be detrimental to mental and physical health outcomes during pregnancy, there is a need for ongoing research of psychosocial factors, as well as underlying demographic and sociocultural variables, that may ... -
Using Advanced Microscopy Techniques for the Study of Macrophage-Cancer Cell Interactions in the Presence of Therapeutic Antibodies
(2017-07-19)The use of monoclonal antibodies represents a rapidly expanding area for cancer therapy. One of the main mechanisms of action of these antibodies is Fcγ receptor-mediated engagement of macrophages and other immune cells. ... -
The U6 snRNA m6A Methyltransferase METTL16 Regulates MAT2A Intron Retention Through Co-Transcriptional Splicing
(2017-07-19)Maintenance of proper levels of the methyl donor S-adenosylmethionine (SAM) is critical for a wide variety of biological processes. We demonstrate that the N6-adenosine methyltransferase METTL16 regulates expression of ... -
Metabolomic Investigation of Melanoma Metastasis in a Patient-Derived Xenograft Mouse Model
(2017-07-19)Metabolic reprogramming is considered a major factor in cellular transformation and tumor initiation, but whether or how metabolism supports tumor metastasis remains an open question. This study seeks to identify metabolic ... -
Anxiety and Anhedonia in Major Depressive Disorder: The Contributing Roles of Neuroticism, Cognitive Control, and Reward Learning
(2017-07-19)Higher levels of anxiety and higher levels of anhedonia in Major Depressive Disorder (MDD) are two clinical presentations linked to poorer depression treatment outcomes. However, the mechanisms contributing to these symptom ... -
Understanding Autism Pathology: Insights from Genetic Mouse Model Manipulation of KCTD13 and SHANK3
(2017-07-19)Copy number variations (CNVs) contribute to the etiology of Autism Spectrum Disorders (ASDs). Deletions/duplications in human chromosomal region 16p11.2 are frequently associated with ASD and other neurodevelopmental ...
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