UT Southwestern Graduate School of Biomedical Sciences
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Welcome to the UT Southwestern Graduate School of Biomedical Sciences’ electronic theses and dissertations (ETD) collection.
Most UT Southwestern ETDs are subject to a default embargo period of two (2) years from the date of degree conferral. These embargoed ETDs are unavailable until the embargo expires.
It might be possible to contact the author for more information before the end of the embargo. For assistance or more information, please contact the UT Southwestern Graduate School of Biomedical Sciences by email.
To verify whether an ETD is available or if you have other questions, please contact etd-utsw@utsouthwestern.edu.
Print theses and dissertations from 1943 to 2004 are located in the Library's Special Collections and Archives (Room E3.314) and are available by appointment. (Note: Former students may request a digitized copy of their work by email, but other users may submit an Interlibrary Loan request.) For more information, contact archives@utsouthwestern.edu.
Recent Submissions
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Integrated Regulation of PKA by Fast and Slow Neurotransmission
(2016-12-19)The neuronal cyclin-dependent kinase 5 (Ckd5) has been shown to be a major regulator of key signaling events downstream of dopamine receptors in the brain. One critical example of such a pathway is the cAMP-dependent protein ... -
The Physiology and Pharmacology of FGF21 in the Exocrine Pancreas
(2019-04-12)The exocrine pancreas comprises about 98% of the total pancreatic tissue. Its main function is the synthesis and secretion of digestive enzymes in order to facilitate nutrient absorption upon feeding. This function is ... -
Measuring Activation of the Cytosolic DNA Sensing Pathway
(2019-04-15)In mammalian cells, DNA is normally sequestered within the confines of the nucleus or mitochondria. Entrance of DNA into the cytosol, whether foreign or self in origin, acts as a danger signal that triggers a host innate ... -
An Isolated Clasp TOG Domain Suppresses Microtubule Catastrophe and Promotes Rescue
(2019-04-12)Microtubules are heavily regulated dynamic polymers of αβ-tubulin that are required for proper chromosome segregation and organization of the cytoplasm. Polymerases in the XMAP215 family use arrayed TOG domains to promote ... -
Synthesis of Six Membered Nitrogen Heterocycles: Boronate Mediated Functionalization of Pyridine and the Selective Synthesis of (+)-Dysoline
(2019-04-11)Nitrogen containing heterocycles play a crucial role in the discovery and development of therapeutically important compounds. As of 2014 an analysis performed by Njarðarson et al. identified that 59 % (640 out of 1086) of ... -
Genetic Analysis of Fic-Mediated BiP AMPylation in Photoreceptors
(2019-04-10)In response to environmental, developmental, and pathological stressors, cells engage homeostatic pathways to maintain their function. The Unfolded Protein Response protects cells from the accumulation of misfolded proteins ... -
With No Gly-Loop Family of Kinases
(2019-04-11)Toxoplasma gondii replicates within a protective organelle called the parasitophorous vacuole (PV). The PV is filled with a network of tubulated membranes, which are thought to facilitate trafficking of effectors and nutrients. ... -
Mycobacterium Tuberculosis Virulence Factor Mpt64 Targets the Endoplasmic Reticulum
(2019-04-10)Mycobacterium tuberculosis, the causative agent of tuberculosis, is one of the most successful human pathogens. One reason for its success is that M. tuberculosis can reside within host macrophages, a cell type that normally ... -
Analysis of the Role of EIF5A in Mammalian Translation
(2019-04-10)MYC is a critical growth-promoting gene that is subject to tight post-transcriptional control. However, the genes and mechanisms that mediate this regulation at the mRNA level are poorly understood. In order to identify ... -
Characterization of Host Factors Affecting Viral Entry
(2019-04-10)Viruses are obligate, intracellular parasites. For a virus to infect a host cell, it must gain access to the interior of the host cell by some means. In animals, this often involves the exploitation of host processes such ... -
Dysbiosis-Associated Changes in Host Metabolism Produce Lactate to Support Enterobacterial Expansion During Inflammation
(2019-04-04)The lumen of the gastrointestinal tract is heavily colonized by microbes, termed the gut microbiota. Under normal conditions, fermentative anaerobes constitute the majority of the gut microbiota. However, during inflammation ... -
Using Molecular and Clinical Data to Stratify Cancer Patients for Precision Medicine
(2019-04-15)Cancers are heterogeneous across different individuals. Insights derived from clinical and/or molecular data could be used to develop robust patient stratification models to tailor treatments for each individual patient, ... -
Genetic Dissection of Synaptic Vesicle Endocytosis
(2019-03-28)Synaptic transmission is mediated by the quantal release of neurotransmitters through the fusion of discrete synaptic vesicles with the presynaptic membrane. To maintain reliable transmission, synaptic vesicles and proteins ... -
Investigating the Transcriptional Regulation of PTF1A and the Function of PRDM13 to Specify Dorsal Spinal Interneurons
(2019-03-28)Transcriptional regulation is a fundamental process required for cell fate specification. During neural development, complex interactions of diverse transcription activators and repressors regulate lineage specific programs. ... -
Inflammasome-Independent Interleukin-1 Beta Drives CD4 T Cell Effector Function and Autoimmune Inflammation
(2019-03-26)Successful generation of protective immunity is a result highly orchestrated interactions between the innate and the adaptive arms of the immune system. Innate immune cells sense the infectious threat to the host and convert ... -
Cholesterol Accessibility in Membranes
(2019-03-19)Cholesterol levels in mammalian cells are tightly regulated to lie within narrow limits. This regulation is achieved by employing multiple feedback mechanisms to regulate both synthesis and uptake of cholesterol. Most of ... -
A Chemically Induced Colitis Screen Reveals the Necessity for Membrane Traffic in Intestinal Homeostasis
(2019-03-21)Inflammatory bowel disease is most commonly a complex disorder caused by the interaction of environmental and genetic aberrations. Under normal conditions, a genetic program actively prevents inflammatory bowel disease, ... -
Molecular Dissection of Hand2 During the Formation of Pacemaker-Like Myocytes During Direct Reprogramming
(2019-03-06)Direct reprogramming of one cell type into another has great promise for regenerative medicine, disease modeling, and lineage specification. Currently, the conversion of fibroblasts into induced cardiomyocytes (iCM) by ... -
Mechanistic Insights into the Role of Munc13 in Synaptic Vesicle Docking, Priming, and Fusion
(2019-03-06)Neurotransmitter release is a fundamental aspect of neuronal communication that relies on the fusion of synaptic vesicles with the presynaptic membrane. These fusion events are tightly regulated by the influx of Ca2+, which ... -
Development of Nitrogen-15- and Carbon-13-Labeled Biochemical Probes for Hyperpolarized Metabolic Imaging
(2019-02-28)13C and 15N dynamic nuclear polarization coupled with nuclear magnetic resonance study provides an opportunity to non-invasively monitor metabolic fluxes in vivo using appropriately designed 13C or 15N enriched metabolic ...
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