UT Southwestern Graduate School of Biomedical Sciences
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Welcome to the UT Southwestern Graduate School of Biomedical Sciences’ electronic theses and dissertations (ETD) collection.
Most UT Southwestern ETDs are subject to a default embargo period of two (2) years from the date of degree conferral. These embargoed ETDs are unavailable until the embargo expires.
It might be possible to contact the author for more information before the end of the embargo. For assistance or more information, please contact the UT Southwestern Graduate School of Biomedical Sciences by email.
To verify whether an ETD is available or if you have other questions, please contact etd-utsw@utsouthwestern.edu.
Recent Submissions
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Regulation of Transcription Through RNA Polymerase II Promoter-Proximal Pausing
(2018-04-12)Cells need to respond to environmental signals in order to adapt to changing stimuli, maintain cell viability and establish fate decisions. One way the cell accomplishes this adaptation is via altering gene expression of ... -
Prevention of Duchenne Muscular Dystrophy by CRISPR/Cas Therapeutic Genome Editing
(2020-01-13)Skeletal muscle is one of the largest tissues in the human body and hence muscle diseases caused by genetic mutations have a profound and systemic impact on human health. Duchenne muscular dystrophy (DMD) is a lethal ... -
Regulation of Mical Redox Post-Translationally-Driven F-Actin Cytoskeletal Dynamics
(2018-04-16)The actin cytoskeleton is critical for multiple diverse cellular behaviors, including the ability of an axon to form, extend, navigate, and synapse with its target. Therefore, an important goal is to understand the mechanisms ... -
Sympathetic Neural Control of Inflammation by ADRB2-Mediated IL-10 Secretion
(2018-04-16)The nervous and immune systems reciprocally regulate their functions through the release of chemical messengers. Norepinephrine (NE), a neurotransmitter released by catecholaminergic nerve endings, allows the sympathetic ... -
Simulated Space Radiation: Effects on Murine Behavior and Neurogenesis
(2018-04-17)An unavoidable consequence of deep space exploration is exposure to high-atomic number, high-energy (HZE) particles, such as 28Si or 56Fe, that comprise galactic cosmic radiation (GCR). It is widely believed that GCR is ... -
Structural Basis of Calcium Transport and Selectivity in the Mitochondrial Calcium Uniporter
(2018-04-13)The mitochondrial calcium uniporter is a highly selective calcium channel localized to the inner mitochondrial membrane. Here, I describe the structure of an MCU ortholog from the fungus Neosartorya fischerii (NfMCU) ... -
The Role of Polyploidy in the Liver and Its Implications for Cancer Therapy
(2018-04-13)The description of liver polyploidy dates back to the 1940s, but its functional roles are still largely unknown. Numerous observations and studies have suggested that liver polyploidy may participate in multiple biological ... -
Perfusion Solution Optimization by Substrate Alteration and Nanoparticle Delivery for Cardiac Hypothermic Machine Perfusion
(2018-04-12)Current heart donor procurement involves a period of cold storage during transport and rarely exceeds 6 hours. While this method reduces myocardial metabolism, it still results in ATP depletion, lactate accumulation, and ... -
Afadin and RhoA Control Pancreatic Endocrine Mass via Lumen Morphogenesis
(2018-04-12)Pancreas is a vital organ responsible for digestion and blood glucose homeostasis in vertebrates. Pancreatic endocrine cells secrete hormones that regulate blood glucose levels, while exocrine cells secrete digestive ... -
Understanding the Atomic-Scale Mechanisms of the Human [alpha]4[beta]2 Nicotinic Acetylcholine Receptor
(2018-04-10)Nicotinic acetylcholine receptors are pentameric ligand-gated ion channels. These receptors are present in the central and peripheral nervous systems where they mediate fast synaptic transmission by allowing the flux of ... -
Stimuli-Responsive Polymer Systems that Respond to Redox Potential and pH for Controlled Drug Release
(2018-04-13)Nanocarriers are widely investigated drug delivery systems that can overcome physiological barriers by tuning nanocarrier size, shape, surface chemistry, targeting ligand conjugation, and material composition. Furthermore, ... -
The Maladaptive Response of Adipose Tissue to High Fat Diet Feeding
(2018-04-05)The ability of organisms, from yeast to humans, to safely store energy as dense hydrophobic carbon chains secured away in lipid droplets represents an incredible evolutionary advantage. The further use of adipocytes as a ... -
Compositional Control of Phase-Separated Cellular Bodies
(2018-04-04)Cellular bodies such as P bodies and PML nuclear bodies (PML NBs) appear to be phase separated liquids organized by multivalent interactions among proteins and RNA molecules. Although many components of various cellular ... -
A Multi-Organ Role for Nocturnin in Post-Transcriptional Regulation of RNA
(2018-04-16)Nocturnin is an RNA-specific nuclease, a circadian deadenylase first discovered in the retina of Xenopus laevis, and is conserved among eukaryotes. Nocturnin is widely expressed in the brain and in the periphery and is ... -
Discovery of Unique Antiviral Pathways in a Bat Viral Reservoir, the Black Flying Fox
(2018-04-03)Bats are asymptomatic reservoirs for a number of viral pathogens. How they manage to host highly pathogenic viruses such a Nipah and Marburg without showing clinical symptoms remains unclear. One of the earliest defenses ... -
Multi-Dimensional Imaging of Cell and Extracellular Matrix Interactions During Corneal Wound Healing
(2018-04-04)Corneal haze is a leading cause of blindness, and may occur after injury, surgery, or chemical burns. The cornea's thickest layer, the stroma, accounts for two-thirds of the eye's refractive power, and contains highly ... -
Investigating Experience-Dependent Plasticity in the Accessory Olfactory Bulb
(2018-04-03)Chemosensory information processing in the mouse accessory olfactory system (AOS) guides the expression of social behavior. After salient chemosensory encounters, the accessory olfactory bulb (AOB) experiences changes in ... -
The Design, Synthesis, and Evaluation of Zwitterionic and Cationic Lipids for In Vivo RNA Delivery and Non-Viral CRISPR/Cas Gene Editing
(2018-03-05)The delivery of nucleic acids is an emerging therapeutic modality in clinical development for the treatment of many genetic diseases. The use of RNA interference (RNAi) as a therapeutic is an exciting and rapidly developing ... -
Assessment of Brain Perfusion and Vascular Compliance with Magnetic Resonance Imaging
(2018-02-28)Brain perfusion is an index that reflects the amount of blood received by the brain tissue in a given time period. Normal brain perfusion ensures that sufficient oxygen, glucose, and other nutrients are delivered to the ... -
Total Synthesis of Mangrolide A
(2018-02-28)The discovery of antibiotics in the 1930s played a critical role in human health by treatment of patients with kinds of infections. During the 'golden era' of antibiotic research, various antibiotics were discovered. The ...
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