UT Southwestern Graduate School of Biomedical Sciences
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Welcome to the UT Southwestern Graduate School of Biomedical Sciences’ electronic theses and dissertations (ETD) collection.
Most UT Southwestern ETDs are subject to a default embargo period of two (2) years from the date of degree conferral. These embargoed ETDs are unavailable until the embargo expires.
It might be possible to contact the author for more information before the end of the embargo. For assistance or more information, please contact the UT Southwestern Graduate School of Biomedical Sciences by email.
To verify whether an ETD is available or if you have other questions, please contact etd-utsw@utsouthwestern.edu.
Print theses and dissertations from 1943 to 2004 are located in the Library's Special Collections and Archives (Room E3.314) and are available by appointment. (Note: Former students may request a digitized copy of their work by email, but other users may submit an Interlibrary Loan request.) For more information, contact archives@utsouthwestern.edu.
Recent Submissions
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A Study in SCAR20 Neurologic Disorder Reveals Defective Cellular Lipid Homeostasis
(2020-11-23)Fatty acids (FAs) are important cellular metabolites that are utilized by the cells to perform important functions such as the generation of ATP, membrane biosynthesis, and cell signaling. Dysregulation in FA processing ... -
The Roles of Codon Usage in Translational and Transcriptional Regulation on Gene Expression
(2020-11-12)Codon usage bias refers to the universal feature of genome that synonymous codons are used at different frequency. Codon usage plays critical roles in determining gene expression levels through impacting multiple fundamental ... -
Structural Studies of Integral Membrane Proteins Involved in GPCR Signaling and Sterol Homeostasis
(2018-11-27)Membrane proteins are crucial molecules for cellular survival, and can take on multiple and diverse roles within the native membrane. In this dissertation, I will detail my efforts to understand and study two different ... -
Mechanistic Link Between DNA Damage Response (DDR) Signaling & Immune Activation
(2018-11-26)Proper maintenance of an intact genome is crucial for cellular homeostasis. To combat threats posed by DNA damage, cells have evolved sophisticated mechanisms - collectively termed as the DNA-damage response (DDR) signaling ... -
Yeast Ataxin-2 (Pbp1) Condensates Regulate TORC1 Activity and Autophagy in Response to Cellular Redox State
(2018-11-26)Yeast ataxin-2, also known as Pbp1 (Poly(A) binding protein-binding protein 1), is an intrinsically disordered protein that has earlier been implicated in stress granule formation, RNA biology, and neurodegenerative disease. ... -
Characterization of the Antiviral Effector IFI6
(2018-11-26)The innate immune response is a critical line of host defense against invading pathogens. The production of interferon (IFN) and the subsequent expression of interferon stimulated genes (ISGs) are major contributors to the ... -
Correction of Hot Spot Mutations in Duchenne Muscular Dystrophy by CRISPR/Cas9 Gene Editing
(2018-11-26)The ability to efficiently modify the genome using CRISPR technology has rapidly revolutionized biology and genetics and will soon transform medicine. Duchenne muscular dystrophy (DMD) represents one of the first monogenic ... -
Factors That Influence Mammalian Enteric Virus Infection
(2018-11-16)RNA viruses are a common cause of emerging diseases due to their vast genetic diversity. This diversity is largely attributed to mutations generated by the error-prone viral RNA-dependent RNA polymerase during replication. ... -
Discovering GCNA: A Novel Regulator of Germline Genomic Stability
(2018-10-15)Germ cells transfer genetic information across generations. Any change in germ line DNA is inherited by succeeding generations. Therefore, germ cell DNA must be protected from both internal and external assault. An advantage ... -
Regulation of the cGAS-STING Pathway in Health and Disease
(2018-11-27)The innate immune system senses non-self or altered-self molecular structures through pattern recognition receptors in order to eliminate pathogens or damaged cells, and restore an organism to its basal physiology. Nearly ... -
NZB/BINJ and NZW/LACJ Embryonic Chimeras Develop Strong Autoimmunity Dependent on NZB/BINJ T Cells
(2018-09-25)The NZB/NZW F1 hybrid develops systemic lupus erythematosus (SLE), displaying features of human disease including spontaneous anti-nuclear antibodies, glomerulonephritis, earlier and more penetrant expression of disease ... -
Regulation of Visceral Adipose Tissue Development and Remodeling in Obesity
(2018-08-31)Mammals possess functionally and anatomically distinct types of adipose tissues that differentially impact metabolic health. Pathologic expansion of visceral white adipose tissue (WAT) in obesity confers significant risk ... -
Cryo-Electron Microscopy of Nicotinic Acetylcholine Receptors
(2018-08-30)Nicotinic acetylcholine receptors are pentameric ligand-gated cation channels. These neurotransmitter-gated cation channels facilitate excitatory neurotransmission in the central and peripheral nervous systems. The ... -
LRBA Restricts Murine Colitis by Regulating Interferon Responses and Autophagy
(2018-11-27)Lrba encodes lipopolysaccharide-responsive and beige like anchor (LRBA) protein, which was originally identified as an LPS-inducible gene in immune cells. LRBA putatively regulates the recycling and degradation of proteins ... -
pH Transistor Nanoprobe Advances Cancer Detection and Surgery
(2015-11-24)Cancer exhibits profound genetic and phenotypic differences, therefore broad yet cancer-specific detection of malignant tumors is challenging. Anatomy-based imaging modalities (e.g., CT, MRI) have good spatial resolution ... -
Role of Primary Cilium-Mediated Signaling in Development, Disease and Cancer
(2018-07-27)The primary cilium serves as an antenna in most vertebrate cells. Dysfunction of the primary cilium is associated with a variety of diseases, called "ciliopathies". Mechanisms underlying ciliogenesis have been well studied. ... -
Defining Tumorigenic Contributions of Meiotic Cancer-Testis Antigens
(2018-07-10)Cancer Testis Antigens (CTAs) are expressed in testis and/or placenta and anomalously activated in a variety of tumors. However, the mechanistic contribution of CTAs to neoplastic phenotypes remains largely unknown. A ... -
Investigating the Role of DIS3L2 in Perlman Syndrome and Wilms Tumor
(2018-06-29)Wilms tumor, while the most common pediatric kidney tumor, has a poorly understood etiology. Several recent studies have uncovered a role for loss of let-7 in its pathogenesis. One crucial mechanism through which let-7 ... -
Chemical Intervention of Influenza Virus mRNA Nuclear Export
(2020-07-15)Influenza A viruses are human pathogens with limited therapeutic options, making it crucial to devise strategies for the identification of new classes of antiviral medications. The influenza A virus genome is constituted ... -
Identifying Autism Spectrum Disorder in a Clinical Sample of Preschool-Aged Children Using the BASC-3 Parent Rating Scales
(2020-07-19)The Behavior Assessment System for Children, Third Edition (BASC-3) is a broadband behavioral rating scale commonly used in medical and educational settings to assess a variety of emotional and behavioral difficulties in ...
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