UT Southwestern Graduate School of Biomedical Sciences
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Welcome to the UT Southwestern Graduate School of Biomedical Sciences’ electronic theses and dissertations (ETD) collection.
Most UT Southwestern ETDs are subject to a default embargo period of two (2) years from the date of degree conferral. These embargoed ETDs are unavailable until the embargo expires.
It might be possible to contact the author for more information before the end of the embargo. For assistance or more information, please contact the UT Southwestern Graduate School of Biomedical Sciences by email.
To verify whether an ETD is available or if you have other questions, please contact etd-utsw@utsouthwestern.edu.
Print theses and dissertations from 1943 to 2004 are located in the Library's Special Collections and Archives (Room E3.314) and are available by appointment. (Note: Former students may request a digitized copy of their work by email, but other users may submit an Interlibrary Loan request.) For more information, contact archives@utsouthwestern.edu.
Recent Submissions
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Role of Primary Cilium-Mediated Signaling in Development, Disease and Cancer
(2018-07-27)The primary cilium serves as an antenna in most vertebrate cells. Dysfunction of the primary cilium is associated with a variety of diseases, called "ciliopathies". Mechanisms underlying ciliogenesis have been well studied. ... -
Defining Tumorigenic Contributions of Meiotic Cancer-Testis Antigens
(2018-07-10)Cancer Testis Antigens (CTAs) are expressed in testis and/or placenta and anomalously activated in a variety of tumors. However, the mechanistic contribution of CTAs to neoplastic phenotypes remains largely unknown. A ... -
Investigating the Role of DIS3L2 in Perlman Syndrome and Wilms Tumor
(2018-06-29)Wilms tumor, while the most common pediatric kidney tumor, has a poorly understood etiology. Several recent studies have uncovered a role for loss of let-7 in its pathogenesis. One crucial mechanism through which let-7 ... -
Chemical Intervention of Influenza Virus mRNA Nuclear Export
(2020-07-15)Influenza A viruses are human pathogens with limited therapeutic options, making it crucial to devise strategies for the identification of new classes of antiviral medications. The influenza A virus genome is constituted ... -
Identifying Autism Spectrum Disorder in a Clinical Sample of Preschool-Aged Children Using the BASC-3 Parent Rating Scales
(2020-07-19)The Behavior Assessment System for Children, Third Edition (BASC-3) is a broadband behavioral rating scale commonly used in medical and educational settings to assess a variety of emotional and behavioral difficulties in ... -
Epithelial Retinoic Acid Receptor Beta Regulates Serum Amyloid A Expression and Vitamin A-Dependent Intestinal Immunity
(2018-08-21)Vitamin A is a dietary component that is essential for the development of intestinal immunity. Vitamin A is absorbed and converted to its bioactive derivatives retinol and retinoic acid by the intestinal epithelium, yet ... -
Outcomes Following Sports-Related Concussion in School-Aged Children and Adolescents: The Influence of Psychological Factors
(2018-07-30)Although neurocognitive performance has been a popular topic of investigation in sports-related concussion, biopsychosocial sequelae have received considerably less attention. We reviewed the literature on emotional and ... -
Neurocognitive and Psychosocial Profiles of Pediatric Multiple Sclerosis and Transverse Myelitis
(2018-07-30)Research shows that youth with multiple sclerosis (MS) are at risk for neuropsychological deficits due to cerebral involvement, but establishing a clear profile remains difficult due to disease complexity. Emerging evidence ... -
A Data-Driven Approach for Deriving Parkinson’s Disease Subtypes and Related Trajectories of Cognitive and Motor Function
(2018-07-27)Parkinson's disease (PD) is a progressive neurological illness that involves a variety of motor and non-motor features, with remarkable heterogeneity in clinical presentation and symptom progression. Previous studies have ... -
Improving Understanding of Cognitive Processing Therapy: Patterns and Predictors of Symptom Change
(2018-07-27)Survivors of military sexual trauma (MST) are more likely to develop posttraumatic stress disorder (PTSD) than survivors of combat and other sexual traumas. Cognitive processing therapy (CPT) has been identified as one of ... -
Cardiovascular Risk Indicators and Health-Related Quality of Life in Women Veterans with PTSD
(2018-07-26)Posttraumatic stress disorder (PTSD) is one of the most prevalent disorders among women veterans treated at the Veterans Health Administration and is associated with a wide range of negative physical health outcomes, ... -
Health Literacy, Spiritual Coping & the Completion of Advance Directives Following a Culturally Sensitive Educational Intervention
(2018-07-25)Based the prior investigations into disparities in advance care planning (ACP) among the African American population, it appears there is a need to identify culturally sensitive educational tools to increase knowledge and ... -
Novel Detection Methods for Chemical Exchange and Application to Breast Cancer Imaging
(2018-07-25)Chemical exchange saturation transfer (CEST) is a novel contrast mechanism that is based on the chemical exchange processes between the protons in water and solutes. CEST can indirectly detect the low concentrated solutes, ... -
Neuropsychological Profiles in Temporal Lobe Epilepsy With and Without a History of Traumatic Brain Injury
(2018-07-25)Neuropsychological deficits have long been observed in those with temporal lobe epilepsy (TLE). Language and verbal memory are often impaired in individuals with left TLE and visuospatial and visual memory can be impaired ... -
T Cell Intrinsic BCAP Links IL1R to the PI3K-mTOR Pathway and Regulates Pathogenic Th17 Differentiation
(2018-07-24)Toll-IL-1R homology (TIR) domains are found within adaptor proteins involved in the signaling of Toll like receptors (TLRs) and Interleukin 1 receptor (IL1R) families. Previous work by our lab identified a TIR domain in ... -
Regulation of Trypanosoma brucei Polyamine Biosynthesis
(2018-07-23)Human African Trypanosomiasis (HAT), also known as Sleeping Sickness, is a disease caused by the protozoan parasite Trypanosoma brucei. About 70 million people are at risk of infection in sub-Saharan Africa. While current ... -
Code Within Codes: Codon Usage Regulate Protein Expression, Structure, and Function
(2018-07-23)Most amino acids are encoded by two to six synonymous genetic codons. Synonymous codons are not used with the same frequency in all organisms, and every organism has its own preferred codon usage bias. Codon usage bias has ... -
EGFR and Akt Signaling in Rhabdomyosarcoma Pathogenesis
(2018-07-25)Rhabdomyosarcoma is an aggressive soft-tissue malignancy comprised microscopically of neoplastic skeletal muscle-lineage precursors that fail to exit the cell-cycle and fuse into syncytial muscle - the underlying pathogenetic ... -
Healthcare Provider and Community Adult Knowledge and Beliefs about Adolescent Sexual and Reproductive Health
(2018-07-20)Sexual and gender minority (SGM) youth face discrimination and health/healthcare disparities in American society (Mustanski, Birkett, Greene, Hatzenbuehler, & Newcomb, 2014a). Researchers have demonstrated connections ... -
Understanding the Conserved and Species-Specific Functions of FOXP2, a Gene Implicated in Speech and Language Development
(2018-07-30)During my dissertation work I sought to better understand the conserved and human-specific functions of FoxP2. Intrigued by the enrichment of FOXP2 in the human subplate layer, I hypothesized that FOXP2 regulates evolutionarily ...
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