UT Southwestern Graduate School of Biomedical Sciences
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Welcome to the UT Southwestern Graduate School of Biomedical Sciences’ electronic theses and dissertations (ETD) collection.
Most UT Southwestern ETDs are subject to a default embargo period of two (2) years from the date of degree conferral. These embargoed ETDs are unavailable until the embargo expires.
It might be possible to contact the author for more information before the end of the embargo. For assistance or more information, please contact the UT Southwestern Graduate School of Biomedical Sciences by email.
To verify whether an ETD is available or if you have other questions, please contact etd-utsw@utsouthwestern.edu.
Recent Submissions
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Investigating the Effects of Particle Radiation Exposure on Lung Carcinogenesis
(2019-04-16)Lung cancer accounts for more cancer-related deaths than any other cancer type among both men and women. The overall increase in radiation risk for human cancer types has been substantiated by the epidemiological data ... -
The Integrated Stress Response Pathway Regulates PD-L1 Translation in Human Lung Cancer
(2019-04-12)Large-scale sequencing studies have comprehensively identified genomic alterations in human cancers, but they lack the ability to distinguish between cancer driver and passenger mutations. Unbiased genetic screens are a ... -
Elucidation of the Mechanism of Action of a Cell Line Selective Toxin
(2019-01-31)A hallmark of targeted cancer therapies is selective toxicity among cancer cell lines. We evaluated results from a viability screen of over 200,000 small molecules to identify two chemical series, oxalamides and benzothiazoles, ... -
Magnetic Resonance Imaging of Cerebral Venous Oxygenation
(2017-05-02)Cerebral venous oxygenation (Yᵥ) is an important biomarker for brain diseases. My dissertation consisted of two studies. The first study aims to investigate the regional Yᵥ in hypertension. Hypertension is known to cause ... -
Nuclear Behaviors of ERK1/2 Signaling
(2017-04-18)The rat sarcoma (Ras)- rapidly accelerated fibrosarcoma (Raf)- mitogen-activated protein kinase/extracellular signal-regulated protein kinase (MAPK/ERK) kinase (MEK)- ERK pathway is essential for proper development and ... -
Toward the Rational Design of Better Antivirals: The Development of cGAMP as an HIV-1 Anti-Retroviral and the Genetic Surveillance of WNV Evolution
(2017-04-17)The innate immune response is the first line of defense against pathogens and thus represents the first hurdle viruses must overcome to cause severe disease in humans. Understanding the consequences of viral evolution can ... -
Differentiation of Normal and Cystic Fibrosis Human Lung Epithelial Cells in a Decellularized and Reconstituted Mouse Lung
(2017-04-14)Engineered lung tissue may eventually address the chronic shortage of transplantable lung tissue and permit modeling of lung disease in a controlled ex vivo environment. However, there are presently no sources of primary ... -
Precursor-Directed Identification of Natural Product Scaffolds
(2017-04-17)The rapid generation of natural product analogs is a fundamental challenge in both the optimization of medicinal potency and exploration of novel biological activity. Previous work with Streptomyces variabilis has demonstrated ... -
Regulation of p190RhoGEF by Activated Rho and Rac GTPases: Amplification and Crosstalk
(2017-04-14)The Rho family of monomeric GTPases regulates a wide range of cellular processes including cytoskeletal structure, motility, cell division, gene transcription, vesicular transport, and various enzymatic activities. Activation ... -
Identification of Biomarker Driven Intervention Opportunities and Advancement of Mechanism of Action Predictions for Anti-Cancer Therapeutics
(2017-04-14)Oncogenic lesions arising during cancer progression provide an attractive target for chemical intervention strategies. The extreme molecular heterogeneity of tumors, however, makes it difficult to identify authentic ... -
Nuclear Export Receptor CRM1 Recognizes Nuclear Export Signals with Diverse Conformations
(2017-04-13)The Chromosome Region of Maintenance 1 or CRM1 protein facilitates export of hundreds of proteins and RNA molecules from eukaryotic cell nuclei. CRM1 recognizes its protein cargoes by their 8-15 residues-long nuclear export ... -
Quantitative Image Analysis in the Study of Neutrophil and Neutrophil-Like HL-60 Chemotaxis
(2017-04-11)Neutrophils are fast-moving first responders of the innate immune system. External chemoattractant signals result in neutrophil polarization: the neutrophil forms a leading edge (front) which constantly protrudes and ... -
Regulatory Mechanisms of Semaphorin/Plexin/Mical-Mediated F-actin Disassembly and Cellular Remodeling
(2017-04-14)Dynamic changes to the actin cytoskeleton modify the shape of cells and their membranous extensions, and underlie diverse developmental and functional events in multiple tissues including migration, navigation, and ... -
Regulation of Hepatic Cholesterol Homeostasis Through Accelerated Degradation of HMG CoA Reductase
(2017-04-06)Cholesterol biosynthesis is rigorously controlled by negative feedback regulation. This reaction occurs, in part, through sterol-accelerated degradation of HMG CoA reductase (HMGCR), which catalyzes the rate-limiting step ... -
Evidence of B Cell Dysregulation in Early Multiple Sclerosis Patients
(2017-04-04)Plasmablasts are a highly differentiated, antibody secreting B cell subset whose prevalence correlates with disease activity in Multiple Sclerosis (MS). For many patients experiencing partial transverse myelitis symptoms, ... -
ApoE Receptors in Alzheimer's and CNS Function
(2017-03-24)Alzheimer's disease (AD) is a currently incurable neurodegenerative disorder and the most common form of dementia over age 65. The predominant genetic risk factor for AD is the ε4 allele of apolipoprotein E (ApoE4). Other ... -
The Functional Roles of the Lin28/let-7 Axis in Tissue Regeneration and Cancer
(2017-04-11)The let-7 microRNAs and their antagonists, the Lin28 RNA-binding proteins (Lin28a and Lin28b), are post-transcriptional regulators well known for their initially discovered role in controlling developmental timing, or ... -
Role of Ceramidase in Regulating Hepatic Lipid Metabolism and Whole Body Insulin Sensitivity
(2017-03-16)Concomitant with the rise in obesity, the prevalence of non-alcoholic fatty liver disease (NAFLD), a newly emerging obesity-related disorder, has also been rising steadily. NAFLD is a chronic liver disease that ranges ... -
Physical, Emotional, and Cognitive Mediators of Therapeutic Expectations for Treating PTSD Related to Military Sexual Trauma
(2017-04-06)PTSD due to military sexual trauma affects both male and female Veterans, and Veterans with MST-related PTSD contend with a host of physical, emotional, and cognitive sequelae. Evidence-based treatments for MST-related ... -
Odorant Responses and Courtship Behaviors Influenced by at4 Neurons in Drosophila
(2017-02-13)In insects, pheromones function as triggers to elicit complex behavior programs, such as courtship and mating. In most species, the neurons tuned to pheromones are localized in a specific subset of olfactory sensilla located ...
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