UT Southwestern Graduate School of Biomedical Sciences
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Welcome to the UT Southwestern Graduate School of Biomedical Sciences’ electronic theses and dissertations (ETD) collection.
Most UT Southwestern ETDs are subject to a default embargo period of two (2) years from the date of degree conferral. These embargoed ETDs are unavailable until the embargo expires.
It might be possible to contact the author for more information before the end of the embargo. For assistance or more information, please contact the UT Southwestern Graduate School of Biomedical Sciences by email.
To verify whether an ETD is available or if you have other questions, please contact etd-utsw@utsouthwestern.edu.
Recent Submissions
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The Pivotal Role of cGAS in Host Defense Against Mycobacterium Tuberculosis and in Particle-Induced Immunity
(2017-11-02)The cGAS-cGAMP-STING pathway is a major DNA sensing pathway in the cytosol. The DNA sensing mechanism is crucial for host defense against bacteria, viruses, and parasites. In the previous study from our lab, the cGAS-STING ... -
Characterization of the Beta-Karyopherin Protein Ipo9 During Germ Cell Differentiation
(2019-12-04)Germ cells participate in the most fascinating process in nature, the fusion of two cells that ultimately give rise to an entire organism. Errors in germ cell development directly affect the fertility of the parent organism ... -
Balancing Renewal and Differentiation of Progenitor Cells in the Developing Kidney
(2017-11-30)Mammalian kidneys perform the important function of blood filtration. All the filtered wastes are concentrated into urine and excreted from the body. The kidney performs these functions through individual functional units ... -
Filopodial Dynamics and Synapse Specification in the Drosophila Visual System
(2017-11-27)How is the synaptic specificity achieved in neural circuits comprised of hundreds of different types of neurons? My dissertation aims to advance our knowledge on this overarching question using the complex visual processing ... -
Synthetic Studies in the Formation of Nitrogen Containing Compounds: From Simple Amines to Complex Natural Products
(2017-11-28)Small nitrogen containing compounds are important building blocks in synthetic chemistry. Not only for biologically active small molecules but in more complex biologically active natural products. Having novel methods to ... -
Regulation of Body Composition by the Microbiota and the Circadian Clock
(2017-11-21)The intestinal microbiota has been identified as an environmental factor that markedly impacts energy storage and body fat accumulation, yet the underlying mechanisms remain unclear. In this dissertation, I show that the ... -
Metabolic Regulation of Transcription Through Compartmentalized NAD+ Biosynthesis
(2017-11-21)Extracellular signaling and nutrient availability are major factors for the cell fate decision. Responds to extracellular information requires metabolic alterations and differential gene expression. Recently emerging concept ... -
Two Psychological Survey Studies: (1) Understanding the Stigma Toward Lung Cancer and (2) Using Research Domain Criteria Project (RDoC) to Predict Remission Rates of Major Depressive Disorder Patients
(2017-11-22)This dissertation is composed of two psychological survey studies. In the first study, people's negative attitudes toward lung cancer are assessed and discussed. The second topic is about predicting the remission rates of ... -
Evolutionary Classification of Protein Domains: From Remote Homology to Family
(2017-11-20)Understanding the evolution of a protein, including both close and distant relationships, often reveals insight into its structure and function. A protein domain classification splits protein into domains and organizes ... -
Dissecting the Function of FARP1 and Rho GTPases in Semaphorin-Plexin Signaling: Structural Perspective
(2017-11-30)The Semaphorin-Plexin signaling is important for regulating axon guidance. Binding of Semaphorin to the Plexin receptor induces the dimerization of Plexin and stimulates its cytoplasmic GAP activity towards Rap, resulting ... -
Identifying Novel Functions of the WNK Pathway
(2017-11-20)The with no lysine [K] (WNK) pathway consists of WNK kinases, their downstream target kinases, oxidative stress responsive (OSR)1 and SPS/Ste20-related proline-alanine-rich kinase (SPAK), and OSR1/SPAK substrates, cation ... -
Dynamic Modulation of Exocyst Interaction Networks Integrates Hippo and mTOR Pathway Response to Pathogen Detection
(2017-11-16)Monomeric RALGTPases, via direct binding to the exocyst (a.k.a Sec6/8 complex), help mount productive cell autonomous responses to trophic and immunogenic signals. However, RAL-exocyst downstream effectors register in a ... -
Characterizing the Cervical Response to Inflammation During Infection-Mediated Preterm Birth
(2017-11-08)Preterm birth, a delivery that occurs prior to 37 weeks of a 40 week gestation in women, is a leading cause of infant morbidity and mortality. Additionally, children born preterm who make it through their first year of ... -
Encoding and Processing of Accessory Olfactory System Odorants
(2017-11-02)The accessory olfactory system is a mouse olfactory subsystem dedicated to the processing of nonvolatile odors originating from the excretions of other animals. Accessory olfactory system activity drives behaviors critical ... -
Spindle Checkpoint Silencing by TRIP13
(2017-10-30)The spindle checkpoint is important for maintaining genomic stability and preventing aneuploidy, a hallmark of cancer. The checkpoint ensures that chromosome segregation does not occur until all sister chromatids are ... -
Regulation of Sister-Chromatid Cohesion
(2017-10-17)Orderly execution of two critical events during the cell cycle--DNA replication and chromosome segregation--ensures the stable transmission of genetic materials. The cohesin complex physically connects sister chromatids ... -
Physical Studies of Actin Nucleation and Conformational Dynamics
(2017-09-06)Actin is a 42 kilodalton ATPase that exists ubiquitously in eukaryotic cells. Unlike other ATPases, however, actin, under suitable conditions, can polymerize, forming helical filaments. Cells, in orchestrating their myriad ... -
The Regulation and Function of Drosophila Acinus
(2017-12-01)Autophagy and growth control are two processes critical to organisms that mutually antagonize and regulate on each other. Several well known connections between these processes have been described, but here I describe a ... -
Development of a Top-Down Proteomics Platform for Characterizing Myelin Basic Protein Proteoforms
(2017-07-31)A top-down proteomic analysis platform for the analysis of myelin basic protein was designed and applied to murine central nervous system tissue. The compatibility of superficially porous (SP) resin for label-free intact ... -
Thioredoxin-1 Inhibition Promotes MLKL Activation: Biochemical Insights Into a Suppressor of the Necroptotic Pathway
(2017-07-13)Necroptosis is an immunogenic caspase-independent cell death program. While mainly serving to defend against viral infection, dysregulated necroptotic signaling contributes to the pathology of a growing number of human ...
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