Browsing UT Southwestern Graduate School of Biomedical Sciences by Issue Date
Now showing items 1-20 of 1279
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Control of Skeletal Muscle Fiber Types by Calcium Signaling Pathways
(2002-08-01)Different patterns of motor nerve activity drive distinctive programs of gene expression in skeletal muscles, thereby establishing a high degree of metabolic and physiological specialization among myofiber subtypes. Previous ... -
Role of I Kappa B Kinase Alpha and I Kappa B Kinase Beta in the Development and Function of B and T Lymphocytes
(2002-12-19)Transcription factor NF-κB plays a key role in regulating the expression of genes involved in the control of the inflammatory and immune response. NF-κB binds to a group of inhibitory proteins, IκBs, in the cytoplasm of ... -
The IRIDESCENT System: An Automated Data-Mining Method to Identify, Evaluate, and Analyze Sets of Relationships Within Textual Databases
(2003-02-01)Individuals are limited in their ability to read, remember and compare relationships within the vast amount of scientific literature available. This is not only because the amount of literature is increasing exponentially, ... -
Characterization of Class D VPS Proteins
(2003-03-11)The vacuole of the yeast Saccharomyces cerevisiae is functionally similar to the mammalian lysosome. The components of the VPS (vacuolar protein sorting) system are responsible for proper delivery of vacuolar biosythetic ... -
Characterization of the T122L Mutation in p53 and Its Protein Product in XPC Mutant Mice
(2003-04-01)Xeroderma Pigmentosum (XP) is a rare genetic disorder characterized by extreme sensitivity to sunlight, and a profound predisposition to skin cancer due to defects in nucleotide excision repair (NER) of DNA. XP patients ... -
Telomere Position Effect in Human Cells
(2003-04-01)Telomeres are tracts of repetitive DNA that cap the ends of linear chromosomes. Each time the chromosome is duplicated, a small amount of telomeric DNA is lost from the end due to factors inherent in the mechanism of DNA ... -
Myogenic BHLH Transcription Factors: Their Overlapping Functions and Direct Regulation of MEF2C Provide a Regulatory Network for the Maintenance and Amplification of Vertebrate Myogenesis
(2003-04-01)The myogenic basic helix-loop-helix (bHLH) genes - Myf5, MyoD, myogenin and MRF4 - exhibit distinct, but overlapping expression patterns during vertebrate myogenesis. Loss-of-function mutations in these genes have defined ... -
Muscle-Specific Regulation of Serum Response Factor by Differential DNA Binding Affinity and Cofactor Interactions
(2003-04-01)Serum response factor (SRF) is a MADS-box transcription factor that regulates muscle-specific and growth factor-inducible genes by binding the CArG box consensus sequence CC(A/T)6GG. Because SRF expression is not ... -
Genetic and Biochemical Analyses of the Necessity for Caspase Activation by the CED4-Domain Proteins, APAF-1 and DARK
(2003-04-03)Activation of caspase proteases by Ced4 domain proteins is a critical step in the induction of programmed cell death, or apoptosis. Understanding of the genetic and biochemical regulation of the mammalian Ced-4 gene, Apaf-1, ... -
Role of Mash1-E Protein Heterodimers in Mash1 Function in the Developing Neural Tube
(2003-05-01)Neural-specific Class II bHLH transcription factors heterodimerize with ubiquitous Class I bHLH E proteins to form complexes required for neural differentiation. There are four known E proteins, HEB, E12, E47 and E2.2, in ... -
The Development of an Informational Video Using Three-Dimentional [sic] Animation to Teach the Fundamentals of the Cellular Process of Apoptosis
(2003-06-01)The goal of this thesis was to create an animated video, with narration, that explains the fundamentals of the process of apoptosis. The objectives were to produce a narrated 3D animation of apoptosis presented in an ... -
The Development of an Instructional Module on the Basics of Web Design for Scientists Interested in Creating a Web Page
(2003-06-01)The purpose of this thesis is to document and explain the development of an instructional module on the basics of web design for scientists interested in developing a web page. This instructional module was created as an ... -
Signal Specific Ubiquitination and Degradation of IkBa
(2003-10-08)The transcription factor Nuclear Factor kB (NF-kB) is retained in the cytoplasm by the action of its inhibitor IkB. Upon phosphorylation by the IKK complex, IkB is rapidly ubiquitinated and targeted for 26S proteasome ... -
Identification of Acyloxyacyl Hydrolase, a Lipopolysaccharide Detoxifying Enzyme, in the Murine Urinary Tract
(2003-10-8)Acyloxyacyl hydrolase (AOAH) is a lipase that removes the secondary fatty acyl chains that are substituted to the hydroxyl groups of glucosamine-linked 3-hydroxyacyl residues in lipid A, the bioactive center of Gram-negative ... -
Transcriptional Regulation of Cardio-Pulmonary Development
(2004-01-14)Organogenesis is a complex process, disruption of which results in developmental anomalies. In recent years, genetic dissection of the pathways involved in cardiogenesis, have shown a striking similarity in molecular ... -
Acanthamoeba spp. Secrete a Mannose-Induced Protein that Correlates with Ability to Cause Acanthamoeba Keratitis
(2004-01-14)Acanthamoeba spp. are ubiquitously distributed in the environment. The trophozoite form can infect the cornea and cause sight-threatening corneal inflammation known as Acanthamoeba keratitis. The pathogenic cascade of ... -
Acyloxyacyl Hydrolase: Studies on Its Regulation and Function in Mus Musculus
(2004-01-14)Acyloxyacyl hydrolase (AOAH) is an enzyme that detoxifies Gram-negative bacterial lipopolysaccharides (LPS) by selectively removing secondary acyl chains from the lipid A moiety. Originally found in neutrophils, it is also ... -
Identification and Characterization of a NEF-Associated Kinase
(2004-05-04)The nef gene encoded by primate lentiviruses is a major determinant of virulence in vivo. It is expressed early in the viral life cycle; its importance likely stems from its ability to prime the host environment for efficient ... -
Transcriptional Regulation of Cardiac Ventricular Development
(2004-05-04)Congenital heart disease is the leading non-infectious cause of death in children. Disruption of cardiac gene expression during development can result in congenital heart defects. Numerous transcription factors regulate ... -
Biofilm Formation by Moraxella Catarrhalis
(2004-05-04)This is the first detailed study of biofilm formation in vitro by the Gram-negative bacterial pathogen Moraxella catarrhalis. Growth of M. catarrhalis in a continuous-culture biofilm system resulted in little detectable ...