Cross-Sectional Study of The Adipokine Resistin Following Kidney Transplant
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For kidney transplant recipients, cardiovascular disease is the number one cause of mortality. Resistin is a recently discovered adipokine that is associated with inflammation and cardiovascular risk. We hypothesized that resistin blood concentrations would be elevated in kidney transplant recipients compared to the general population. We used a single center cross-sectional study comparing 76 kidney transplant recipients with 42 normal controls over the age of 18. Measurements included demographics, IL-6, resistin, and glomerular filtration rate (calculated through the CKD-EPI equation). Spearman's correlation and linear regression were used for analysis. Kidney transplant recipients were found to be younger (46.9 ± 11.5 vs 58.5 ± 10 years, p < 0.01) and have a higher incidence of diabetes (29% vs 9%, p < 0.05). Resistin was found to be elevated (28.4 ± 11.5 vs 11.1 ± 6.0 ng/mL, p < 0.001) while body mass index (29.7 ± 6.2 vs 29.1 ± 4.4) and IL-6 (7.1 ± 7.5 vs 9.5 ± 13.9 pg/mL) were not statistically different. Resistin levels in kidney transplant recipients were found to be correlated with patient age (p < 0.01) and time since transplant (p < 0.05). Both remained significant when also controlling for race, body mass index, glomerular filtration rate and diabetic status (p < 0.05). When looking at both kidney transplant recipients and controls, age was still a significant determinant as well as being within the transplant recipient group (p < 0.05). In conclusion, resistin is elevated in kidney transplant recipients independent of glomerular function and may play a role in the increased prevalence and incidence of cardiovascular disease.