BTB-Kelch Proteins and TAk1 Kinase N Immune Function

Date

2006-12-19

Journal Title

Journal ISSN

Volume Title

Publisher

Abstract

BTB-kelch proteins are putative components of E3 ligases with a BTB domain at the N terminus and several kelch repeats at the C terminus. KLHL6 and mKELCH are two members of this family. Conditional ablation of Klhl6 in B cells resulted in mild developmental phenotypes in bone marrow precursors. The number of peripheral B cells was decreased by half, and responded defectively in germinal center formation after antigen stimulations. mKELCH is a novel protein cloned from hearts. Knocked-in LacZ expressed predominantly at muscles and several photosensitive organs. TAK1 is a member of MAPKKK. Deletion of TAK1 prevented the maturation of CD4+ or CD8+ single positive thymocytes, leading to reduction of T cells in peripheral tissues. Thymocytes lacking TAK1 failed to activate NF-κB and JNK, and were prone to apoptosis upon stimulation. All three mouse models have provided important evidences in elucidating biological functions for each protein in vivo.

General Notes

Table of Contents

Subjects

MAP Kinase Kinase Kinases, Thymus Gland, Immunity

Citation

Related URI