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dc.contributor.advisorZhan, Xiaoweien
dc.creatorMa, Tsung-weien
dc.date.accessioned2020-01-02T18:22:40Z
dc.date.available2020-01-02T18:22:40Z
dc.date.created2017-12
dc.date.issued2017-11-22
dc.date.submittedDecember 2017
dc.identifier.urihttps://hdl.handle.net/2152.5/7741
dc.description.abstractThis dissertation is composed of two psychological survey studies. In the first study, people's negative attitudes toward lung cancer are assessed and discussed. The second topic is about predicting the remission rates of major depressive disorder patients with patients' self-reported questionnaires. In the first topic, I analyzed data from The Lung Cancer Project, an online survey study, to assess both explicit and implicit attitudes expressed by the four participant groups: health care professionals, cancer patients, caregivers and the general public. Negative attitudes toward lung cancer were detected among all these participant groups. I also discovered several demographic factors significantly associated with negative attitudes toward lung cancer. Furthermore, I investigated the association between state-level perceptions of lung cancer (including both explicit and implicit attitudes) and rates of treatment (drug treatment rates or total treatment rates, including surgery, chemotherapy, radiation, and immunotherapy) for lung cancer patients in the corresponding states. In the second topic, existing data from the Combining Medications to Enhance Depression Outcomes (CO-MED) trial were utilized to develop a data-driven method for mapping the behavioral factors to the constructs defined in Research Domain Criteria (RDoC). And I used the defined behavioral factors from CO-MED to discover patient subgroups. In further analysis, I found that the discovered patient subgroups have significantly different remission rates to the antidepressant treatment, which indicates that there are three endo-phenotypes in major depression disorder.en
dc.format.mimetypeapplication/pdfen
dc.language.isoenen
dc.subjectAttitude of Health Personnelen
dc.subjectHealth Personnelen
dc.subjectLung Neoplasmsen
dc.subjectMental Disordersen
dc.subjectPsychiatryen
dc.subjectResearchen
dc.subjectSocial Stigmaen
dc.titleTwo Psychological Survey Studies: (1) Understanding the Stigma Toward Lung Cancer and (2) Using Research Domain Criteria Project (RDoC) to Predict Remission Rates of Major Depressive Disorder Patientsen
dc.typeThesisen
dc.date.updated2020-01-02T18:22:40Z
dc.type.materialtexten
thesis.degree.grantorUT Southwestern Medical Centeren
thesis.degree.departmentGraduate School of Biomedical Sciencesen
thesis.degree.nameDoctor of Philosophyen
thesis.degree.levelDoctoralen
thesis.degree.disciplineIntegrative Biologyen
dc.contributor.committeeMemberXie, Yangen
dc.contributor.committeeMemberXiao, Guanghuaen
dc.contributor.committeeMemberSchiller, Joan H.en
dc.contributor.committeeMemberGazdar, Adien
dc.identifier.oclc1134689294
dc.creator.orcid0000-0001-7628-6189


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