Neural Correlates of Item and Item-Context Memory Encoding

Simple item page
dc.contributor.advisorTamminga, Carolen
dc.contributor.committeeMemberRugg, Michael D.en
dc.contributor.committeeMemberMonteggia, Lisaen
dc.contributor.committeeMemberPark, Denise C.en
dc.creatorMattson, Julia Tang, 1987-en
dc.date.accessioned2017-06-02T15:23:50Z
dc.date.available2017-06-02T15:23:50Z
dc.date.created2015-05
dc.date.issued2013-07-29
dc.date.submittedMay 2015
dc.date.updated2017-06-02T15:12:44Z
dc.description.abstractThe neural correlates of the formation of episodic memories -- or memory for an item and its context -- have been studied using a functional neuroimaging procedure known as the 'subsequent memory procedure'. In this procedure, neural activity associated with later remembered versus later forgotten study items is contrasted and the identified brain regions -- demonstrating 'subsequent memory effects' -- can be considered candidate loci of neurocognitive operations supporting successful episodic encoding. The aim of the present work was to disambiguate the neural correlates of item and item-context (source) memory encoding, and investigate age-related differences in subsequent memory effects as well as the relationship between such effects and memory performance. The findings reported in Chapter 2 investigated whether age-related attenuation of negative subsequent item and item-item memory effects extends to the encoding of item-context memories. It is demonstrated that, unlike negative effects for item and item-item memory, encoding of negative effects for item-context associations does not attenuate with age and the level of disengagement of neural regions promotes better memory performance. The findings reported (from the same fMRI experiment as Chapter 2) in Chapter 3 addressed the question of whether the phenomenon of age-related over-recruitment of frontal regions during encoding extends to encoding of non-verbal materials. It is found that, contrary to prior studies utilizing verbal materials, recruitment of the right frontal cortex in task-stimuli combinations that promote bilateral effects in young subjects is beneficial for memory encoding. The experiment in Chapter 4 aimed to elucidate differences in the encoding of different context types. The results of this study suggest that negative effects differ depending on the type of source feature being encoded. The findings from these studies shed light on the circumstances under which older adults benefit from engagement/disengagement of different neural regions and the circumstances in which age-related changes in subsequent memory effects are observed.en
dc.format.mimetypeapplication/pdfen
dc.identifier.oclc988778284
dc.identifier.urihttps://hdl.handle.net/2152.5/4101
dc.language.isoenen
dc.subjectAgingen
dc.subjectAssociation Learningen
dc.subjectBrainen
dc.subjectMemoryen
dc.titleNeural Correlates of Item and Item-Context Memory Encodingen
dc.typeThesisen
dc.type.materialtexten
thesis.degree.departmentGraduate School of Biomedical Sciencesen
thesis.degree.disciplineNeuroscienceen
thesis.degree.grantorUT Southwestern Medical Centeren
thesis.degree.levelDoctoralen
thesis.degree.nameDoctor of Philosophyen

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
MATTSON-DISSERTATION-2015.pdf
Size:
1.86 MB
Format:
Adobe Portable Document Format
Download

License bundle

Now showing 1 - 2 of 2
No Thumbnail Available
Name:
license.txt
Size:
2.13 KB
Format:
Plain Text
Description:
Download
No Thumbnail Available
Name:
LICENSE.txt
Size:
1.84 KB
Format:
Plain Text
Description:
Download

Collections

UT Southwestern Graduate School of Biomedical Sciences