The Regulation and Function of Drosophila Acinus

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dc.contributor.advisorJohnson, Jane E.en
dc.contributor.committeeMemberSmith, Dean P.en
dc.contributor.committeeMemberPan, Duojiaen
dc.contributor.committeeMemberKrämer, Helmuten
dc.creatorTyra, Lauren Katherineen
dc.date.accessioned2020-01-02T18:21:26Z
dc.date.available2020-01-02T18:21:26Z
dc.date.created2017-12
dc.date.issued2017-12-01
dc.date.submittedDecember 2017
dc.date.updated2020-01-02T18:21:27Z
dc.description.abstractAutophagy and growth control are two processes critical to organisms that mutually antagonize and regulate on each other. Several well known connections between these processes have been described, but here I describe a new link. Using Drosophila melanogaster as a model system, my thesis research has identified Acinus and Atg1, already known for their functions in autophagy, as growth suppressors. Further, my data show that this suppression is, at least in part, mediated by Atg1 phosphorylating and thereby inhibiting the pro-growth transcriptional co-activator Yorkie. Genetic gain- and loss-of function experiments indicate that this Atg1 function depends on Acinus. This work provides a new role for Atg1 in inhibition of growth and thereby adding a new regulatory pressure on Yorkie. Furthermore, my data indicate that Acinus’ function in promoting basal autophagy is based on its starvation-independent activation of the Atg1 kinase.en
dc.format.mimetypeapplication/pdfen
dc.identifier.oclc1134688876
dc.identifier.urihttps://hdl.handle.net/2152.5/7731
dc.language.isoenen
dc.subjectAutophagyen
dc.subjectCyclin-Dependent Kinase 5en
dc.subjectDrosophila melanogasteren
dc.subjectDrosophila Proteinsen
dc.subjectProtein Processing, Post-Translationalen
dc.subjectTranscription Factorsen
dc.titleThe Regulation and Function of Drosophila Acinusen
dc.typeThesisen
dc.type.materialtexten
thesis.degree.departmentGraduate School of Biomedical Sciencesen
thesis.degree.disciplineNeuroscienceen
thesis.degree.grantorUT Southwestern Medical Centeren
thesis.degree.levelDoctoralen
thesis.degree.nameDoctor of Philosophyen

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