BTB-Kelch Proteins and TAk1 Kinase N Immune Function
| dc.contributor.advisor | Chen, Zhijian J. | en |
| dc.creator | Liu, Hong-Hsing | en |
| dc.date.accessioned | 2010-07-12T17:59:20Z | |
| dc.date.available | 2010-07-12T17:59:20Z | |
| dc.date.issued | 2006-12-19 | |
| dc.description.abstract | BTB-kelch proteins are putative components of E3 ligases with a BTB domain at the N terminus and several kelch repeats at the C terminus. KLHL6 and mKELCH are two members of this family. Conditional ablation of Klhl6 in B cells resulted in mild developmental phenotypes in bone marrow precursors. The number of peripheral B cells was decreased by half, and responded defectively in germinal center formation after antigen stimulations. mKELCH is a novel protein cloned from hearts. Knocked-in LacZ expressed predominantly at muscles and several photosensitive organs. TAK1 is a member of MAPKKK. Deletion of TAK1 prevented the maturation of CD4+ or CD8+ single positive thymocytes, leading to reduction of T cells in peripheral tissues. Thymocytes lacking TAK1 failed to activate NF-κB and JNK, and were prone to apoptosis upon stimulation. All three mouse models have provided important evidences in elucidating biological functions for each protein in vivo. | en |
| dc.format.digitalOrigin | born digital | en |
| dc.format.medium | Electronic | en |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.oclc | 424500398 | |
| dc.identifier.uri | https://hdl.handle.net/2152.5/414 | |
| dc.language.iso | en | en |
| dc.subject | MAP Kinase Kinase Kinases | en |
| dc.subject | Thymus Gland | en |
| dc.subject | Immunity | en |
| dc.title | BTB-Kelch Proteins and TAk1 Kinase N Immune Function | en |
| dc.type | Thesis | en |
| dc.type.genre | dissertation | en |
| dc.type.material | Text | en |
| thesis.date.available | 2006-12-19 | |
| thesis.degree.department | Graduate School of Biomedical Sciences | en |
| thesis.degree.discipline | Integrative Biology | en |
| thesis.degree.grantor | UT Southwestern Medical Center | en |
| thesis.degree.level | Doctoral | en |
| thesis.degree.name | Doctor of Philosophy | en |