Epithelial Retinoic Acid Receptor Beta Regulates Serum Amyloid A Expression and Vitamin A-Dependent Intestinal Immunity

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dc.contributor.advisorWinter, Sebastian E.en
dc.contributor.committeeMemberKliewer, Steven A.en
dc.contributor.committeeMemberHooper, Lora V.en
dc.contributor.committeeMemberShiloh, Michaelen
dc.creatorGattu, Surekaen
dc.creator.orcid0000-0001-7559-7989
dc.date.accessioned2020-09-01T21:10:21Z
dc.date.available2020-09-01T21:10:21Z
dc.date.created2018-08
dc.date.issued2018-08-21
dc.date.submittedAugust 2018
dc.date.updated2020-09-01T21:10:21Z
dc.description.abstractVitamin A is a dietary component that is essential for the development of intestinal immunity. Vitamin A is absorbed and converted to its bioactive derivatives retinol and retinoic acid by the intestinal epithelium, yet little is known about how epithelial cells regulate vitamin A-dependent intestinal immunity. Here I show that epithelial cell expression of the transcription factor retinoic acid receptor β (RARβ) is essential for vitamin A-dependent intestinal immunity. Epithelial RARβ activated vitamin A-dependent expression of serum amyloid A (SAA) proteins by binding directly to Saa promoters. In accordance with the known role of SAAs in regulating Th17 cell effector function, epithelial RARβ promoted IL-17 production by intestinal Th17 cells. More broadly, epithelial RARβ was required for the development of key vitamin A-dependent adaptive immune responses, including CD4+ T cell homing to the intestine and the development of immunoglobulin A-producing intestinal B cells. My findings provide insight into how the intestinal epithelium senses dietary vitamin A status to regulate adaptive immunity and highlight the role of epithelial cells in regulating intestinal immunity in response to diet.en
dc.format.mimetypeapplication/pdfen
dc.identifier.oclc1192326114
dc.identifier.urihttps://hdl.handle.net/2152.5/8809
dc.language.isoenen
dc.subjectImmunity, Mucosalen
dc.subjectIntestinal Mucosaen
dc.subjectReceptors, Retinoic Aciden
dc.subjectSerum Amyloid A Proteinen
dc.subjectVitamin Aen
dc.titleEpithelial Retinoic Acid Receptor Beta Regulates Serum Amyloid A Expression and Vitamin A-Dependent Intestinal Immunityen
dc.typeThesisen
dc.type.materialtexten
thesis.degree.departmentGraduate School of Biomedical Sciencesen
thesis.degree.disciplineMolecular Microbiologyen
thesis.degree.grantorUT Southwestern Medical Centeren
thesis.degree.levelDoctoralen
thesis.degree.nameDoctor of Philosophyen

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