Left Atrial Enlargement Is Related to Diastolic Dysfunction in Obese Subjects

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dc.contributor.otherSarma, Satyamen
dc.contributor.otherHieda, Michinarien
dc.contributor.otherLevine, Benjamin D.en
dc.creatorAiad, Norman N.en
dc.date.accessioned2017-01-31T00:39:22Z
dc.date.available2017-01-31T00:39:22Z
dc.date.issued2017-01-17
dc.descriptionThe 55th Annual Medical Student Research Forum at UT Southwestern Medical Center (Monday, January 17, 2017, 2-5 p.m., D1.600)en
dc.description.abstractPURPOSE: Obesity is linked to diastolic dysfunction and left atrial enlargement (LAE). The mechanisms responsible for LAE in obesity are unknown. We hypothesized that diastolic dysfunction, which is common in obesity, is the mechanism through which LAE occurs. METHODS: 27 middle-aged, obese patients (8M: 19F, 49±7years) with an average body mass index (BMI) of 38 ±5 kg/m2 were compared to age and sex matched non-obese healthy controls. Diastolic function (IVRT; isovolumic relaxation time, Vp: propagation velocity) was assessed using echocardiography. Left atrium (LA) size was measured using 3D echocardiogram, and normalized to height to account for the effects of body size. RESULTS: Obese individuals had a significantly enlarged atrial volume when compared to healthy individuals (35.9 ± 8 vs. 19.4 ± 10.5 mL/m; p<0.01). Obese patients had a significantly shorter IVRT when compared to non-obese patients (68 ± 11 vs 100 ± 16 msec; p<0.01). Obese patients also had a significantly faster Vp when compared to non-obese patients (75 ± 19 vs 56 ± 13 cm/sec; p<0.01). In obese subjects, there was a significant negative-relationship between LA volume index and IVRT (R2=0.27; p<0.05) as well as a significant positive-relationship between LA volume index and Vp (R2=0.18; p<0.05). CONCLUSIONS: Obese patients have larger LA and markers of elevated LA filling pressures (IVRT and Vp) compared to age matched controls. LAE in obesity may be a driven by sub-clinical alterations in diastolic function and left atrial filling pressures.en
dc.description.sponsorshipSouthwestern Medical Foundationen
dc.identifier.citationAiad, N. N., Sarma, S., Hieda, M., & Levine, B. D. (2017, January 17). Left atrial enlargement is related to diastolic dysfunction in obese subjects. Poster session presented at the 55th Annual Medical Student Research Forum, Dallas, TX. Retrieved from https://hdl.handle.net/2152.5/3998en
dc.identifier.urihttps://hdl.handle.net/2152.5/3998
dc.language.isoenen
dc.relation.ispartofseries55th Annual Medical Student Research Forumen
dc.subjectClinical Research and Case Reportsen
dc.subject.meshAtrial Fibrillationen
dc.subject.meshAtrial Function, Leften
dc.subject.meshDiastoleen
dc.subject.meshHeart Atriaen
dc.subject.meshObesityen
dc.titleLeft Atrial Enlargement Is Related to Diastolic Dysfunction in Obese Subjectsen
dc.typePresentationen

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