Transcriptional Regulation of Adult Neurogenesis by NRSF/REST and NeuroD1

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dc.contributor.advisorHsieh, Jennyen
dc.creatorUre, Kerstin Mariaen
dc.date.accessioned2011-08-26T17:35:21Z
dc.date.available2011-08-26T17:35:21Z
dc.date.issued2011-08-10
dc.description.abstractNeurogenesis in the adult brain is a complex and lifelong process that is regulated by multiple pathways and is sensitive to many external stimuli. Two critical regulatory factors in this process are NRSF/REST and NeuroD1. NRSF/REST, a transcriptional repressor that binds a specific NRSE site and recruits corepressors and chromatin remodeling machinery to repress its target genes, is critical for maintenance of the neural stem cell pool and for proper pacing of neuronal differentiation. NeuroD1, a bHLH transcription factor, is necessary for the terminal differentiation, maturation, and survival of newborn neurons. In addition, both factors are necessary for the neurogenic response to both physiological and pathological stimuli, which may induce neurogenesis through different pathways. Thus, NRSF/REST and NeuroD1 are necessary for neurogenesis to occur correctly, to persist throughout the organism’s lifespan, and to respond to external stimuli.en
dc.identifier.oclc759112616
dc.identifier.urihttps://hdl.handle.net/2152.5/889
dc.language.isoenen
dc.subjectNeurogenesisen
dc.subjectRepressor Proteinsen
dc.subjectNeural Stem Cellsen
dc.titleTranscriptional Regulation of Adult Neurogenesis by NRSF/REST and NeuroD1en
dc.typeThesisen
dc.type.materialTexten
thesis.date.available2013-08-10
thesis.degree.departmentGraduate School of Biomedical Sciencesen
thesis.degree.disciplineIntegrative Biologyen
thesis.degree.grantorUT Southwestern Medical Centeren
thesis.degree.levelDoctoralen
thesis.degree.nameDoctor of Philosophyen

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