Transitioning Between Preparatory and Precisely Sequenced Neuronal Activity in Production of a Skilled Motor Behavior

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dc.contributor.advisorPfeiffer, Brad E.en
dc.contributor.committeeMemberMeeks, Julian P.en
dc.contributor.committeeMemberLi, Wen-Hongen
dc.contributor.committeeMemberFiolka, Retoen
dc.contributor.committeeMemberRoberts, Todden
dc.creatorDaliparthi, Vamsi Krishnaen
dc.creator.orcid0000-0001-6358-729X
dc.date.accessioned2021-09-17T17:58:39Z
dc.date.available2021-09-17T17:58:39Z
dc.date.created2019-08
dc.date.issued2019-06-18
dc.date.submittedAugust 2019
dc.date.updated2021-09-17T17:58:40Z
dc.description.abstractPrecise neural sequences are associated with the production of well-learned skilled behaviors. Yet, how neural sequences arise in the brain remains unclear. In songbirds, premotor projection neurons in the cortical song nucleus HVC are necessary for producing learned song and exhibit precise sequential activity during singing. Using cell-type specific calcium imaging we identify populations of HVC premotor neurons associated with the beginning and ending of singing-related neural sequences. We characterize neurons that bookend singing-related sequences and neuronal populations that transition from sparse preparatory activity prior to song to precise neural sequences during singing. Recordings from downstream premotor neurons or the respiratory system suggest that pre-song activity may be involved in motor preparation to sing. These findings reveal population mechanisms associated with moving from non-vocal to vocal behavioral states and suggest that precise neural sequences begin and end as part of orchestrated activity across functionally diverse populations of cortical premotor neurons.en
dc.format.mimetypeapplication/pdfen
dc.identifier.oclc1268338246
dc.identifier.urihttps://hdl.handle.net/2152.5/9614
dc.language.isoenen
dc.subjectLearningen
dc.subjectMotor Cortexen
dc.subjectNeural Pathwaysen
dc.subjectNeuronsen
dc.subjectVocalization, Animalen
dc.titleTransitioning Between Preparatory and Precisely Sequenced Neuronal Activity in Production of a Skilled Motor Behavioren
dc.typeThesisen
dc.type.materialtexten
thesis.degree.departmentGraduate School of Biomedical Sciencesen
thesis.degree.disciplineBiomedical Engineeringen
thesis.degree.grantorUT Southwestern Medical Centeren
thesis.degree.levelDoctoralen
thesis.degree.nameDoctor of Philosophyen

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