High-Resolution Array Comparative Genomic Hybridization Identifies Common Targets in Rhabdomyosarcoma

Simple item page
dc.contributor.advisorCameron, Scotten
dc.creatorPaulson, Vera Ashleyen
dc.date.accessioned2012-08-15T14:22:36Z
dc.date.available2012-08-15T14:22:36Z
dc.date.issued2012-08-15
dc.description.abstractRhabdomyosarcoma (RMS) accounts for nearly 50 percent of the soft tissue sarcomas that affect children. There are two major histological variants, alveolar (ARMS) and embryonal (ERMS). Both are defined as sarcomas that show exclusive evidence of muscle differentiation, but differ in their pathogenesis and prognosis. ARMS typically occurs in adolescents, presents as disease of the extremities, has a higher risk of metastasis or treatment-resistance, and in 75% of cases, is characterized by the presence of the PAX3/7:FOXO1A translocation. ERMS is associated with a younger age at presentation, sites of disease other than the extremities, a more favorable clinical outcome, and the absence of consistent chromosomal translocations. Here we used high-density array-based comparative genomic hybridization to examine the genomes of RMS to identify common programs that drive tumor pathogenesis.en
dc.identifier.oclc812529150
dc.identifier.urihttps://hdl.handle.net/2152.5/1112
dc.language.isoenen
dc.subjectRhabdomyosarcomaen
dc.subjectGene Expression Regulation, Neoplasticen
dc.subjectReceptor, Fibroblast Growth Factor, Type 4en
dc.titleHigh-Resolution Array Comparative Genomic Hybridization Identifies Common Targets in Rhabdomyosarcomaen
dc.typeThesisen
dc.type.materialTexten
thesis.date.available2014-07-10
thesis.degree.departmentGraduate School of Biomedical Sciencesen
thesis.degree.disciplineCancer Biologyen
thesis.degree.grantorUT Southwestern Medical Centeren
thesis.degree.levelDoctoralen
thesis.degree.nameDoctor of Philosophyen

Files

Collections

UT Southwestern Graduate School of Biomedical Sciences