The Maladaptive Response of Adipose Tissue to High Fat Diet Feeding

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dc.contributor.advisorGupta, Rana K.en
dc.contributor.committeeMemberScherer, Philippen
dc.contributor.committeeMemberBrekken, Rolf A.en
dc.contributor.committeeMemberKittler, Ralfen
dc.contributor.committeeMemberKim, Jamesen
dc.creatorMorley, Thomas S.en
dc.date.accessioned2020-06-02T21:05:19Z
dc.date.available2020-06-02T21:05:19Z
dc.date.created2018-05
dc.date.issued2018-04-05
dc.date.submittedMay 2018
dc.date.updated2020-06-02T21:05:19Z
dc.description.abstractThe ability of organisms, from yeast to humans, to safely store energy as dense hydrophobic carbon chains secured away in lipid droplets represents an incredible evolutionary advantage. The further use of adipocytes as a professional lipid storage cells emphasizes the importance and benefit of safe long term energy storage. As lipids are capable of acting intracellularly as both signaling molecules and detergents, there proper storage and sequestration is of pivotal importance if they are to be used for the maintenance of energy homeostasis. With the safe storage of energy dense lipids and their later partitioning to other metabolically active tissues, the production of ATP can continue to occur in multiple organs during periods of food deprivation. With this in mind, many early investigators saw the importance of adipose tissue, though its true importance was not recognized till relatively recently.en
dc.format.mimetypeapplication/pdfen
dc.identifier.oclc1156324531
dc.identifier.urihttps://hdl.handle.net/2152.5/8310
dc.language.isoenen
dc.subjectAdipocytesen
dc.subjectAdipose Tissueen
dc.subjectDiet, High-Faten
dc.subjectInsulin Resistanceen
dc.titleThe Maladaptive Response of Adipose Tissue to High Fat Diet Feedingen
dc.typeThesisen
dc.type.materialtexten
thesis.degree.departmentGraduate School of Biomedical Sciencesen
thesis.degree.disciplineGenetics and Developmenten
thesis.degree.grantorUT Southwestern Medical Centeren
thesis.degree.levelDoctoralen
thesis.degree.nameDoctor of Philosophyen

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