Identification and Characterization of EFL-3, a C. Elegans E2F Transcription Factor

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dc.contributor.advisorAvery, Leonen
dc.creatorYoshimoto, Jennifer Ann Winnen
dc.date.accessioned2011-12-14T20:19:13Z
dc.date.available2011-12-14T20:19:13Z
dc.date.issued2011-12-14
dc.description.abstractThe development of an organism depends on cells receiving and executing their specific fates, though how this process is regulated remains largely unknown. Here, we identify a mechanism by which a specific cell fate, apoptosis, is determined through the cooperative efforts of Hox and E2F proteins. E2F transcription factors are critical, conserved regulators of the cell cycle and apoptosis. However, little is known about the two most recently discovered mammalian E2Fs—-E2F7 and E2F8. In the nematode Caenorhabditis elegans, we identify a novel E2F7/8 homolog, EFL-3, and show that EFL-3 functions cooperatively with LIN-39, providing the first example in which these two major developmental pathways—-E2F and Hox—-are able to directly regulate the same target gene. Our studies demonstrate that LIN-39 and EFL-3 function in a cell type-specific context to regulate transcription of the egl-1 BH3 only cell death gene and determine cell fate during development.en
dc.identifier.oclc769764372
dc.identifier.urihttps://hdl.handle.net/2152.5/954
dc.language.isoenen
dc.subjectCaenorhabditis elegansen
dc.subjectE2F Transcription Factorsen
dc.subjectCaenorhabditis elegans Proteinsen
dc.titleIdentification and Characterization of EFL-3, a C. Elegans E2F Transcription Factoren
dc.typeThesisen
dc.type.materialTexten
thesis.date.available2011-12-12
thesis.degree.departmentGraduate School of Biomedical Sciencesen
thesis.degree.disciplineGenetics and Developmenten
thesis.degree.grantorUT Southwestern Medical Centeren
thesis.degree.levelDoctoralen
thesis.degree.nameDoctor of Philosophyen

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