Does Reelin Affect Recovery from a Stroke?

Simple item page
dc.contributor.otherHerz, Joachiumen
dc.contributor.otherStowe Ann M.en
dc.contributor.otherLane-Donovan, Courtneyen
dc.creatorDeSai, Charismaen
dc.date.accessioned2016-06-20T15:52:09Z
dc.date.available2016-06-20T15:52:09Z
dc.date.issued2016-01-19
dc.descriptionThe 54th Annual Medical Student Research Forum at UT Southwestern Medical Center (Monday, January 19, 2016, 2-5 p.m., D1.700)en
dc.description.abstractReelin is an extraceullular glycoprotein that modulates synaptic plasticity and increases long-term potentiation. Since Reelin has neuroprotective effects, we were interested to see if Reelin plays a role in recovery after significant neurological damage. Earlier studies with reeler mice showed that mice lacking Reelin have increased susceptibility to stroke and suffer more damage post-stroke. Since Reelin is important in neuronal migration during development, it is possible that the effects seen were due to improper brain development, instead of Reelin deficiency itself. Instead of using Reeler mice, we used the Reelin conditional knockout(cKO) mouse model. Thus, we were able to see the effects of Reelin loss while permitting normal brain development. Stroke size and post-stroke behavior were investigated after inducing transient middle cerebral artery occlusion in four-month-old Reelin cKO mice. No significant difference was seen between wild type and Reelin cKO mice in infarct size or behavior, suggesting that while Reelin does play in important function in the brain, it does not play a significant role in post-stroke recovery.en
dc.description.sponsorshipSouthwestern Medical Foundationen
dc.identifier.citationDeSai, C., Herz, J., Stowe, A. M., & Lane-Donovan, C. (2016, January 19). Does reelin affect recovery from a stroke? Poster presented at the 54th Annual Medical Student Research Forum, Dallas, TX. Retrieved from https://hdl.handle.net/2152.5/3254en
dc.identifier.urihttps://hdl.handle.net/2152.5/3254
dc.language.isoenen
dc.relation.ispartofseries54th Annual Medical Student Research Forumen
dc.subjectBasic Research and Disease Modelsen
dc.subject.meshBrainen
dc.subject.meshCell Adhesion Molecules, Neuronalen
dc.subject.meshExtracellular Matrix Proteinsen
dc.subject.meshInfarction, Middle Cerebral Arteryen
dc.subject.meshNerve Tissue Proteinsen
dc.subject.meshSerine Endopeptidasesen
dc.subject.meshStrokeen
dc.titleDoes Reelin Affect Recovery from a Stroke?en
dc.typePresentationen

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
DeSai_FinalPoster_MSRF2016.pdf
Size:
384.69 KB
Format:
Adobe Portable Document Format
Description:
PDF--public access
Download

Collections

Annual Medical Student Research Forum