Health-Related Quality of Life in Morphea
| dc.contributor.committeeMember | Jacobe, Heidi | en |
| dc.contributor.committeeMember | Bernstein, Ira | en |
| dc.contributor.committeeMember | Cayce, Rachael | en |
| dc.creator | Klimas, Natasha | en |
| dc.date.accessioned | 2016-06-27T20:09:43Z | |
| dc.date.available | 2016-06-27T20:09:43Z | |
| dc.date.created | 2014-05 | |
| dc.date.issued | 2015-03-20 | |
| dc.date.submitted | May 2014 | |
| dc.date.updated | 2016-06-27T19:49:07Z | |
| dc.description.abstract | OBJECTIVE: Little is known about health-related quality of life (HRQOL) of patients with morphea (localized scleroderma). We determined the impact of morphea on HRQOL and clinical and demographic correlates of HRQOL. METHODS: Cross sectional survey of Morphea in Adults and Children (MAC) cohort. RESULTS: Morphea impairs HRQOL. Patients were particularly affected with respect to emotional well-being and concerns that the disease will progress to their internal organs. Patients with morphea had worse skin-specific HRQOL than those with other skin diseases, including non-melanoma skin cancer, vitiligo, and alopecia (lowest P <.0001). The morphea population was found to have significantly worse global HRQOL scores than the general U.S. population for all subscales (all P ≤.004) with the exception of bodily pain. Comorbidity (r =.35-.51, P ≤ .0029 -.0001) and symptoms of pruritus (r =.38 -.64, P ≤.001-.0001) and pain (r =.46-.74, P <.0001) were associated with impairment in multiple domains of skin-specific and global HRQOL. Physician-based measures of disease severity correlated with patient-reported HRQOL. CONCLUSION: Patients with morphea have negative impact on HRQOL particularly if symptoms or concerns regarding internal manifestations are present. Providers should be aware of this when evaluating and treating patients. | en |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.oclc | 952355703 | |
| dc.identifier.uri | https://hdl.handle.net/2152.5/3318 | |
| dc.language.iso | en_US | en |
| dc.subject | Emotions | en |
| dc.subject | Quality of Life | en |
| dc.subject | Scleroderma, Localized | en |
| dc.title | Health-Related Quality of Life in Morphea | en |
| dc.type | Thesis | en |
| dc.type.material | text | en |
| thesis.degree.department | UT Southwestern Medical School | en |
| thesis.degree.discipline | Research | en |
| thesis.degree.grantor | UT Southwestern Medical Center | en |
| thesis.degree.level | Doctoral | en |
| thesis.degree.name | M.D. with Distinction | en |