Serotonin Reuptake Inhibitor Use During Pregnancy: Perinatal Outcomes
| dc.contributor.advisor | Dashe, Jodi S. | en |
| dc.creator | Jordan, Allison E. | en |
| dc.date.accessioned | 2010-07-12T18:50:27Z | |
| dc.date.available | 2010-07-12T18:50:27Z | |
| dc.date.issued | 2008-04-10 | |
| dc.description.abstract | OBJECTIVE: To assess severity of neonatal behavioral syndrome (NBS) in infants of serotonin reuptake inhibitor (SRI)-treated pregnancies, compared with infants of women with psychiatric illness not treated with medication. METHODS: Retrospective cohort study of pregnancies followed in a prenatal clinic for women with psychiatric illness. Infants of women who received SRI medication through delivery (SRI-treated) were compared with those who did not receive treatment or discontinued medication before the last month of pregnancy (SRI-untreated). NBS was defined as one or more of the following: jitteriness, irritability, lethargy, hypotonia, hypertonia, hyperreflexia, apnea, respiratory distress, vomiting, poor feeding, or hypoglycemia. RESULTS: Findings of NBS were identified in 28% of 46 SRI-treated pregnancies and 17% of 59 untreated pregnancies. There were no differences in rates of prematurity (4% vs. 7%), fetal growth restriction (6% vs. 2%), transfer to a higher nursery for NBS (11% vs. 10%), respiratory abnormality (7% vs. 5%), or hospitalization duration among infants with NBS findings (2 vs. 6 days). CONCLUSIONS: Findings of NBS were identified in 28% of SRI-exposed neonates. However, these infants were not more likely than unexposed infants to be admitted to a higher nursery, experience respiratory abnormalities, or have prolonged hospitalization. | en |
| dc.format.digitalOrigin | born digital | en |
| dc.format.medium | Electronic | en |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.oclc | 664111290 | |
| dc.identifier.uri | https://hdl.handle.net/2152.5/688 | |
| dc.language.iso | en | en |
| dc.subject | Serotonin Uptake Inhibitors | en |
| dc.subject | Depressive Disorder | en |
| dc.subject | Infant Behavior | en |
| dc.title | Serotonin Reuptake Inhibitor Use During Pregnancy: Perinatal Outcomes | en |
| dc.type | Thesis | en |
| dc.type.genre | thesis | en |
| dc.type.material | Text | en |
| thesis.date.available | 2009-04-10 | |
| thesis.degree.department | UT Southwestern Medical School | en |
| thesis.degree.discipline | Research | en |
| thesis.degree.grantor | UT Southwestern Medical Center | en |
| thesis.degree.level | Doctoral | en |
| thesis.degree.name | M.D. with Distinction | en |