Depressive Symptoms and Subclinical Vascular Disease: A Cross-Cultural Comparison

dc.contributor.advisorCullum, C. Munroen
dc.contributor.committeeMemberWeiner, Myron F.en
dc.contributor.committeeMemberHynan, Linda S.en
dc.contributor.committeeMemberKing, Kevin S.en
dc.contributor.committeeMemberRossetti, Heidien
dc.contributor.committeeMemberDeschner, Martinen
dc.creatorMoore, Patricia Sinclairen
dc.date.accessioned2013-09-24T19:23:09Z
dc.date.available2013-09-24T19:23:09Z
dc.date.created2013-08
dc.date.issued2013-07-25
dc.date.submittedAugust 2013
dc.date.updated2013-09-24T18:49:04Z
dc.description.abstractWhile rates of depression are similar across ethnic groups, severity of symptoms and disability related to depression are greater in African Americans when compared with other groups (Breslau, Kendler, Su, Gaxiola-Aguilar, & Kessler, 2005). Markers of subclinical cardiovascular disease have been associated with depression, and rates of most cardiovascular risk factors are higher in African Americans than Caucasians (Shaya, Gu, & Saunders, 2007). Whereas rates of atherosclerosis are similar across these groups (Jain et al., 2004), atherosclerosis has been shown to be associated with depression in mostly Caucasian samples (Bus et al., 2011; Gebara & Santos, 2010). A more direct marker of subclinical cerebrovascular impact is cerebral white matter hyperintensity volume (WMHv). Differences in WMHv have been reported across ethnic groups, and WMHv is more closely associated with the cardiovascular risk factors that are higher in African Americans. White matter hyperintensities (WMH) have been independently associated with increased depressive symptoms in late-life depression (Pompili et al., 2007; 2008; Sneed et al., 2011; Tham, Woon, Sum, Lee, & Sim, 2011), although the relationship between vascular disease and depression is poorly understood. This study aimed to examine the relationship between atherosclerosis, WMHv, and depressive symptoms in Caucasians and African Americans over age 50 to determine the association between subclinical vascular disease and depressive symptoms across ethnic groups. To this end, specific measures of subclinical vascular diseases (measures of atherosclerosis, WMHv) were compared to identify the best predictors of depressive symptoms within ethnic groups.en
dc.format.mimetypeapplication/pdfen
dc.identifier.oclc858948587
dc.identifier.urihttps://hdl.handle.net/2152.5/1356
dc.language.isoenen
dc.subjectCardiovascular Diseaseen
dc.subjectDepressionen
dc.subjectAfrican Americansen
dc.titleDepressive Symptoms and Subclinical Vascular Disease: A Cross-Cultural Comparisonen
dc.typeThesisen
dc.type.materialTexten
thesis.date.available2013-09-01
thesis.degree.departmentGraduate School of Biomedical Sciencesen
thesis.degree.disciplineClinical Psychologyen
thesis.degree.grantorUT Southwestern Medical Centeren
thesis.degree.levelDoctoralen
thesis.degree.nameDoctor of Philosophyen

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
MOORE-DISSERTATION-2013.pdf
Size:
848.28 KB
Format:
Adobe Portable Document Format